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Research

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research Acetyl zingerone methyl ether protects hair against oxidative damage incurred during and after treatment with permanent dyes and helps extend longevity of newly developed hair colour

August 2024 in “International Journal of Cosmetic Science”

This study found that acetyl zingerone methyl ether (MAZ) in hair dyes and haircare products may reduce oxidative damage, improve hair condition, and enhance the longevity and quality of dyed hair color.

research Permanent hair dyes and bladder cancer risk

24 citations , January 2001 in “International Journal of Cancer”

This study from Los Angeles supports the idea that using permanent hair dye may increase bladder cancer risk in US women, especially those with a slow NAT2 acetylation phenotype.

research Design and Development of a Shampoo with Dark Semi-Permanent Dyes for Gradual Gray Hair Coverage

April 2026 in “Cosmetics”

This study developed and tested a shampoo with semi-permanent dyes designed to gradually cover gray hair, reporting maintained stability and effective gray–black coloration on high-canities hair tresses through eight wash cycles.

research Effects of semi-permanent hair dyes and conditioning polymers on the colour enhancing properties of shampoo formulations

November 2016 in “University of the Arts London Research Online (University of the Arts London)”

This study concluded that adding polymeric conditioning actives to shampoos improved color retention in permanently dyed hair, while additional cationic dyes at certain pH levels weakly dyed the hair directly.

Allergens of Permanent Hair Dyes Induce Epidermal Damage, Skin Barrier Loss, and IL-1 Alpha Increase in Epidermal In Vitro Model

research Allergens of permanent hair dyes induces epidermal damage, skin barrier loss and IL-1 α increase in epidermal in vitro model

12 citations , December 2017 in “Food and chemical toxicology”

This study found that mixtures used in permanent hair dyes had irritant effects on reconstructed human epidermis, while individual ingredients alone did not.

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Clinics

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Community Join

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community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Are permanent hair gains even possible?

in Chat 13 upvotes 1 year ago

Hair regrowth from treatments like minoxidil, RU58841, and finasteride is not permanent; stopping these treatments typically results in hair loss resuming. Beard hair can become permanent with minoxidil use, unlike scalp hair, which requires ongoing treatment to maintain gains.

community Minoxidil permanent face changes?

4 upvotes 4 years ago

Excessive use of topical minoxidil led to unwanted facial changes and side effects. The user plans to switch to oral minoxidil with microneedling for hair regrowth.

community RU58841 Permanently Fixed Balding In Unexpected Way.

in Satire 123 upvotes 10 months ago

The user humorously describes trying various hair loss treatments, including minoxidil, finasteride, and RU58841, with a satirical twist involving psychedelic experiences and imaginary entities. They mistakenly used LSD instead of RU58841 and plan to continue experimenting with other substances.

community Does Nuking Scalp DHT Theoretically Make Minoxidil Gains Permanent?

in Minoxidil 36 upvotes 1 year ago

Minoxidil gains are not permanent without continued use, even with DHT suppression. Combining treatments like Dutasteride, Finasteride, and RU58841 may help maintain hair, but stopping Minoxidil typically results in hair loss.

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Learn

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learn Platelet-Rich Plasma

Are Platelet results permanent, or does hair loss return once treatment stops? Hair loss typically returns after stopping PRP treatment, as effects are not permanent.

learn Hair Transplant

Is a hair transplant permanent? Transplanted hair is generally permanent but requires ongoing care to maintain results.
Are NeoGraft results permanent? Transplanted hair from NeoGraft is permanent, but surrounding hair may still thin.
Is a beard transplant permanent? Beard transplants are generally considered a permanent solution for facial hair loss.
All 4 questions on Hair Transplant →

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Experts

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