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Did you mean Perifollicular Hyperpigmentation?

Glossary Perifollicular Hyperpigmentation

darkening of skin around hair follicles due to inflammation

Perifollicular hyperpigmentation refers to the darkening of the skin around hair follicles. This condition often occurs due to inflammation or irritation, such as from acne, folliculitis, or certain hair removal methods, leading to an increased production of melanin in the affected areas.

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Research

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research Subclinical speckled perifollicular melanosis of the scalp.

7 citations , March 2003 in “PubMed”

This study reported that in men with androgenic alopecia, a distinct subclinical hyperpigmentation pattern was observed in the scalp, associated with baldness severity and possibly linked to local melanin production by pilosebaceous units.

research Presentations of Cutaneous Disease in Various Skin Pigmentations: Keratosis Pilaris

February 2026 in “HCA Healthcare Journal of Medicine”

This review discusses identifying keratosis pilaris, its common mimics, and its associated skin diseases across different skin tones but reports no new results.

research Faculty Opinions recommendation of Dermal adipose tissue secretes HGF to promote human hair growth and pigmentation.

March 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

This study found that human dWAT regulates hair growth and pigmentation through HGF secretion, highlighting potential novel targets for treating hair growth and pigmentation disorders.

research Dermoscopy of discoid lupus erythematosus: Report of two cases

13 citations , July 2014 in “The Journal of Dermatology”

Dermoscopy helped diagnose discoid lupus erythematosus in two patients without needing skin biopsies.

research Lichen Planopilaris With Foreign-Body Granuloma

5 citations , April 2014 in “The American Journal of Dermatopathology”

This article reports on a typical case of lichen planopilaris with foreign-body granulomas around hair shaft material, suggesting these may be an additional criterion for diagnosing late-stage LPP/FFA.

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community What is this pigmentation around my follicles?

in Chat 29 upvotes 1 year ago

The conversation discusses potential causes of pigmentation around hair follicles, suggesting sebum buildup, autoimmune conditions, or dermatitis. Treatments mentioned include finasteride, dutasteride, and an anti-inflammatory diet, with a recommendation to consult a doctor for a proper diagnosis.

community Making your own RT1640 in China

4 years ago

RT1640, a combination of cyclosporin A, minoxidil, and RT175, is discussed as a potential treatment for hair regrowth and repigmentation. The unique formulation aims to enhance hair follicle growth and restore hair pigment without the negative side effects of immunosuppressants.

community Perifollicular Fibrosis and its role in androgenetic alopecia. Is Aminexil/Kopexil a must for anyone with AGA?

5 upvotes 4 years ago

Aminexil/Kopexil may help reduce hair loss by addressing perifollicular fibrosis in androgenetic alopecia, but it lacks the extensive clinical backing of finasteride and minoxidil. Some users find it effective, but availability and cost are issues, especially in the US where it's not FDA-approved.

community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

11 upvotes 2 years ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

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