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GlossaryPerifollicular Infiltrate

accumulation of immune cells around hair follicles

Perifollicular infiltrate refers to the accumulation of immune cells around hair follicles. This can be a sign of inflammation or an immune response, often seen in conditions like alopecia areata, where the body's immune system mistakenly attacks hair follicles, leading to hair loss.

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research Perifollicular Inflammation and Follicular Spongiosis in Androgenetic Alopecia

1 citations, September 2021 in “Journal of The American Academy of Dermatology”

Hair loss in both Androgenetic Alopecia and Alopecia Areata is often accompanied by inflammation around hair follicles, but the location and severity of this inflammation varies.

research Histological Features of Peripilar Signs Associated with Androgenetic Alopecia

95 citations, January 2004 in “Archives of Dermatological Research”

Peripilar signs can help diagnose androgenetic alopecia and reveal its cause.

research The Functional Relevance of the Type 1 Cytokines IFN-γ and IL-2 in Alopecia Areata of C3H/HeJ Mice

20 citations, November 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

IFN-γ and IL-2 are important for T cell activation in hair loss in mice.

research Alopecia Areata in a Rhesus Monkey (Macaca Mulatta)

16 citations, April 2007 in “Journal of Medical Primatology”

The monkey's hair loss was due to an autoimmune disease, not genetics.

research Topical Minoxidil in Alopecia Areata: No Effect on the Perifollicular Lymphoid Infiltration

33 citations, July 1992 in “Journal of Investigative Dermatology”

Minoxidil doesn't affect perifollicular lymphoid infiltration in alopecia areata patients.

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community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 1 year ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community How I started reversing Male Pattern Baldness naturally ?

in Question 6 upvotes 7 years ago

The user reversed male pattern baldness using a pro-thyroid diet, lifestyle changes, and scalp stimulation exercises, without Minoxidil or Finasteride. They reported reduced dandruff, itchiness, oiliness, and experienced hair regrowth and thickening over 15 months.

community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

in Research/Science 13 upvotes 7 months ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community Novel effect of sildenafil (cialis) on hair growth

in Research/Science 21 upvotes 2 years ago

Sildenafil (Viagra) shows potential for hair growth by enhancing dermal papilla cell proliferation and stimulating perifollicular vessel formation. Users discuss the possibility of using Cialis (tadalafil) similarly, noting its benefits and side effects.

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