30 citations
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October 1994 in “Journal of Cutaneous Pathology” The document described a case of a patient with multiple perifollicular fibromas and analyzed existing literature on the condition. Perifollicular fibroma was identified as a cutaneous hamartomatous proliferation involving the pilar connective tissue sheath, with a histological appearance of concentric collagen fibers around an unaltered hair follicle. Clinically, these fibromas were typically multiple and located on the face and upper trunk. The presentation was similar to Birt‐Hogg‐Dubé syndrome, which also included fibrofolliculomas, trichodiscomas, and acrochordons. The document suggested that earlier reports of multiple perifollicular fibromas might have been unrecognized cases of Birt‐Hogg‐Dubé syndrome.
September 2020 in “Advances in anatomic pathology” A woman's large nose growth was initially misdiagnosed, but later confirmed to be giant rhinophyma after full removal and examination.
4 citations
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August 1991 in “The Journal of Dermatology” The document reported a rare case of a pedunculated follicular hamartoma on the nasal septum of a 77-year-old Japanese male. The nodule measured 11x11x10 mm and was skin-to-pink colored. Histopathological examination revealed a well-formed dilated hair follicle at the tumor's central pore, containing keratin debris and vellus hairs. Epithelial cells proliferated from the central follicle to the peripheral epidermis, forming long thin strands or immature follicle-like structures. A primary germinal bud with thick concentric collagen fibers and sparse elastic fibers was a distinctive feature. Although the tumor showed characteristics of a trichofolliculoma with desmoplasia, trichogenic trichoblastomas, and perifollicular fibromas, it was more accurately described as a pedunculated follicular hamartoma due to its pathological and clinical features.
36 citations
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March 2011 in “Nature Communications” Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.
48 citations
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May 2008 in “Drug Discovery Today: Disease Mechanisms” Hair follicles offer promising targets for delivering drugs to treat hair and skin conditions.