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GlossaryOsteopontin

protein aiding bone remodeling and immune regulation

Osteopontin is a protein found in the body that plays a crucial role in bone remodeling and immune system regulation. It helps in the attachment of cells to the bone matrix and is involved in processes like inflammation and tissue repair, making it significant in both health and disease contexts.

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research Osteopontin Gene Is Expressed in the Dermal Papilla of Pelage Follicles in a Hair-Cycle-Dependent Manner

17 citations, December 2001 in “Journal of Investigative Dermatology”

The osteopontin gene is active in a specific part of rat hair follicles during a certain hair growth phase and might affect hair cycle and diseases.

research Gene Expression of Osteopontin in Alopecia Areata: A Case-Controlled Study

1 citations, October 2014 in “Skin Pharmacology and Physiology”

People with alopecia areata have higher levels of osteopontin, which might be important in the disease's development, but this doesn't relate to how severe the disease is.

research Identification of an Osteopontin-Derived Peptide That Binds Neuropilin-1 and Activates Vascular Cells

September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

FOL-026 peptide can help repair blood vessels and promote growth, offering potential treatment for vascular diseases.

research FGF7-Dependent Inhibition of Human Hair Growth by an Osteopontin-Derived Peptide: A Novel Solution for Hirsutism and Hypertrichosis

April 2018 in “Journal of Investigative Dermatology”

A new peptide, FOL-005, may help treat excessive hair growth by reducing a hair growth promoter, FGF7.

research Elevated Expression of Osteopontin Splice Variants in Nonmelanoma Skin Cancer Compared to Normal Skin and Adult Keratinocytes

April 2018 in “Journal of Investigative Dermatology”

Nonmelanoma skin cancers have higher levels of certain osteopontin variants than normal skin.

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community Thoughts and Opinions on upcoming hairloss treatments?

in Chat 11 upvotes 9 months ago

The conversation is about optimism for new hair loss treatments like Stemson's bioengineering, osteopotin, SCUBE3, GT20029, and Verteprofin, and inquires about other notable treatments.

community He used Dutasteride for 20 YEARS: TL;DR Slight gains and largely stable for 20 years.

in Treatment 25 upvotes 9 months ago

John has experienced slight hair gains and stability over 20 years using Dutasteride, which is more effective than Finasteride in reducing scalp DHT and maintaining hair. Dutasteride at 0.5mg daily has a similar side effect profile to Finasteride, but at higher doses, it may increase the risk of sexual side effects.

community Amplifica and AMP-303 clinical phase 1

in Research/Science 9 upvotes 11 months ago

Amplifica is testing a compound called AMP-303 for hair loss, but it's not Scube3 or osteopontin. The timing for the results from the clinical trial is unknown.

community Coegin Pharma to release Follicopeptide (FOL005) by Q2 2025

in Treatment 118 upvotes 3 months ago

Follicopeptide (FOL005) by Coegin Pharma will launch as a cosmetic hair growth treatment by Q2 2025, showing similar efficacy to finasteride. Users discuss the benefits and skepticism of releasing hair loss treatments as cosmetics rather than drugs.

community Found an interesting little article

in Research/Science 6 upvotes 4 months ago

A new painless microneedle patch shows promise in reversing hair loss. The discussion focuses on potential new treatments beyond common options like Minoxidil, finasteride, and RU58841.

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