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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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research Transforming Growth Factor-Beta in Stem Cells and Tissue Homeostasis
TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.
research Induction of osteoblastic differentiation of neural crest-derived stem cells from hair follicles
The study demonstrated that neural crest-derived hair follicle cells from mice could be induced to differentiate into osteoblast-like cells, suggesting potential for bone regenerative therapies. Using whisker follicles from protein zero-Cre/floxed-EGFP double transgenic mice, researchers cultured and treated these cells, finding that 95% proliferated and 76.2% expressed mesenchymal stem cell markers. The cells expressed osteogenic markers and produced mineralized matrices when stimulated with bone morphogenetic protein-2. Additionally, the presence of 1α,25-dihydroxyvitamin D3 altered expression of osteoprotegerin and induced RANKL production, leading to the formation of multinucleated osteoclasts in co-cultures. These findings highlighted the osteoblastic differentiation potential of NC-derived hair follicle cells.
research Bilateral Eyelid Pseudoptosis From Lipogranulomas of the Preaponeurotic Fat Pads
Surgical removal of abnormal fat pads fixed the woman's eyelid issue caused by likely silicone injections.
research Ishige Sinicola Extract Stimulates Osteoblast Proliferation and Differentiation via the Bone Morphogenetic Protein 2/Runt-Related Gene 2 Signaling Pathway
Ishige sinicola extract helps bone-building cells grow and mature, which could aid in treating osteoporosis.
research Free Papers Medical and Surgical: Hair and Nails
The document discusses hair and nail conditions, updates on treatments for alopecia, and controversies around finasteride use.
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5 / 6 resultscommunity Microneedling and aloe vera to recruit stem cells.
Microneedling combined with aloe vera may stimulate dormant stem cells in hair loss areas. Minoxidil is also suggested for better results.
community One year on finasteride has reversed some aging
Finasteride and minoxidil use resulted in a more youthful appearance and improved skin. There is debate about their effects on collagen and skin aging, with no solid evidence supporting significant changes due to finasteride.
community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications
The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.
community Do you believe these studies are real or just fear mongering
Finasteride can regrow hair but may cause depression and suicidal thoughts in some users. The connection between finasteride and mental health issues is debated, with some attributing it to pre-existing conditions or stress.
community Why isn't anyone using Way-316606? If it works then it grows a full head of hair back on most people
Way-316606 is considered a potential hair loss treatment but is avoided due to safety concerns and lack of research. Minoxidil and Finasteride are preferred as established treatments.