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GlossaryOuter Root Sheath Keratinocytes (ORSCs)

specialized cells in the hair follicle's outer layer

Outer Root Sheath Keratinocytes are specialized cells found in the outer layer of the hair follicle. These cells play a crucial role in the growth and regeneration of hair, as they provide structural support and contribute to the formation of the hair shaft. For professionals, it's important to note that these keratinocytes are involved in the hair cycle's anagen (growth) phase and can be a focus in studies related to hair loss and treatments for conditions like alopecia.

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research Hair Follicle Stem Cell Replication Stress Drives IFI16/STING-Dependent Inflammation in Hidradenitis Suppurativa

33 citations, April 2020 in “Journal of Clinical Investigation”

Stress in hair follicle stem cells causes inflammation in a chronic skin condition through a specific immune response pathway.

research Mechanism of Action of Androgen in Hair Follicles

25 citations, July 1994 in “Journal of dermatological science”

Testosterone affects hair follicles differently across body sites, with beard hair follicles showing more activity of a specific enzyme and presence of androgen receptors compared to scalp hair.

research The Effect of Cilostazol, a Phosphodiesterase 3 (PDE3) Inhibitor, on Human Hair Growth with Dual Promoting Mechanisms

21 citations, April 2018 in “Journal of Dermatological Science”

Cilostazol helps hair grow by making hair root cells grow faster and changing growth factor levels.

Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

research Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

14 citations, June 2018 in “Frontiers in pharmacology”

Green tea compound EGCG helps mink hair follicles grow by affecting certain cell growth pathways.

research The Local Hypothalamic–Pituitary–Adrenal Axis in Cultured Human Dermal Papilla Cells

9 citations, June 2020 in “BMC Molecular and Cell Biology”

Stress hormone CRF can cause hair loss by affecting hair growth cells and hormones.

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