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GlossaryOuter Root Sheath Keratinocytes (ORSCs)

specialized cells in the hair follicle's outer layer

Outer Root Sheath Keratinocytes are specialized cells found in the outer layer of the hair follicle. These cells play a crucial role in the growth and regeneration of hair, as they provide structural support and contribute to the formation of the hair shaft. For professionals, it's important to note that these keratinocytes are involved in the hair cycle's anagen (growth) phase and can be a focus in studies related to hair loss and treatments for conditions like alopecia.

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research Acquired Curved Hair Is Caused by Fusion of Multiple Hair Matrix Cells

February 2024 in “Journal of Dermatological Science”

Curved hair can develop when hair cells merge abnormally during growth.

research Mechanism of Action of Androgen in Hair Follicles

25 citations, July 1994 in “Journal of dermatological science”

Testosterone affects hair follicles differently across body sites, with beard hair follicles showing more activity of a specific enzyme and presence of androgen receptors compared to scalp hair.

research The Effect of Cilostazol, a Phosphodiesterase 3 (PDE3) Inhibitor, on Human Hair Growth with Dual Promoting Mechanisms

21 citations, April 2018 in “Journal of Dermatological Science”

Cilostazol helps hair grow by making hair root cells grow faster and changing growth factor levels.

research Differentiation of Nestin-Negative Human Hair Follicle Outer Root Sheath Cells Into Neurons In Vitro

5 citations, January 2017 in “Molecular Medicine Reports”

Human hair follicle cells can be turned into neural stem cell-like cells, which might help treat brain diseases.

research The Local Hypothalamic–Pituitary–Adrenal Axis in Cultured Human Dermal Papilla Cells

9 citations, June 2020 in “BMC Molecular and Cell Biology”

Stress hormone CRF can cause hair loss by affecting hair growth cells and hormones.

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