research Effects of ameloblast that regulates the expression of nuclear factor 1-C and odontoblast on hair follicle regeneration
Ameloblasts and odontoblasts help hair follicles regenerate.
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5 / 1000+ resultsresearch Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome
This study identified mutations in the SREBF1 gene that impair SREBP1 function, potentially contributing to IFAP syndrome by affecting skin, hair, and eye development.
research 4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the NRF2/HO‐1 signalling pathway
In this study, researchers found that 4-Octyl itaconate (4-OI) inhibited cisplatin-induced ferroptosis and protected auditory cells by activating the NRF2/HO-1 signaling pathway, suggesting a potential therapeutic approach for reducing hearing loss associated with cisplatin treatment.
research AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma
This study found that small molecule AP-1 inhibitors may selectively target SMO inhibitor-resistant basal cell carcinoma cells characterized by specific markers, potentially enhancing combinatorial cancer therapies.
research Particulate matter exposure induces maternal scalp hair loss after birth in C57/B6 mouse via alteration of inflammatory and apoptotic pathways
In a mouse model, this study found that exposure to PM2.5 leads to significant postpartum hair loss, apparent via morphological changes and elevated markers of inflammation, apoptosis, and fibrosis, potentially exacerbated by changes in hormone receptors and stem cell populations.
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5 / 422 resultscommunity Why do some have no change even on nuclear stacks ?
Some people see significant hair regrowth using treatments like finasteride and minoxidil, while others experience little to no improvement even with comprehensive treatment plans. Factors such as individual sensitivity to DHT may influence the effectiveness of these hair loss treatments.
community Naturally high T (1,100+) causing diffuse thinning while on Dut
A 26-year-old male with high testosterone is experiencing diffuse hair thinning despite using a comprehensive treatment regimen including dutasteride, oral minoxidil, RU58841, ketoconazole shampoo, microneedling, and low-level laser therapy. Suggestions include adjusting dutasteride dosage, monitoring iron levels, and consulting a dermatologist for further evaluation.
community We cooked fam? 1 Year on Dut + Oral Min after years of Fin (some mistakes made & details in comments)
The user switched from finasteride and topical minoxidil to dutasteride and oral minoxidil, experiencing some hair shedding but maintaining hair quality. Suggestions include increasing oral minoxidil dosage, considering a hair transplant, and using dermarolling, while some users recommend stopping treatment altogether.
community Before and after 1 year of oral fin + topic min still 0 improvements
The conversation is about hair loss treatments, specifically the lack of improvement after one year of using oral finasteride and topical minoxidil. Suggestions include switching to stronger medications like dutasteride and oral minoxidil, considering a hair transplant, and possibly using microneedling or tretinoin.
community Oral Finasteride 1.25mg - 9 Months
The user has been taking oral finasteride 1.25mg daily for 9 months but is still experiencing hair recession. They plan to try topical minoxidil and consider oral minoxidil and dutasteride if needed.
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