109 citations
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March 2011 in “Journal of controlled release” This study found that econazole nitrate delivered via MPEG-dihexPLA micelles significantly increased skin deposition compared to Pevaryl® cream, potentially enhancing drug bioavailability and clinical efficacy.
1 citations
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January 2022 in “Journal of Pharmaceutical Sciences” This study developed a stable, cosmetically appealing formulation for the topical delivery of the peptide FOL-005, enhancing skin permeation and maintaining stability by keeping the peptide solid and in a water-free environment with particle sizes under 10 µm.
September 2024 in “Journal of the American Academy of Dermatology” In this prospective, placebo-controlled study, the researchers observed a significant reduction in hair shedding in women after applying the combined topical treatment DA-OTC-002, containing synephrine and TAAR agonists, compared to placebo, showing a 62.5% average reduction with no reported adverse events.
January 2026 in “ChemistrySelect” This study demonstrates that a newly developed bio-based, dual-phasic hair serum offers a sustainable and effective alternative to traditional silicone-based serums, enhancing hair cuticle integrity and consumer appeal while supporting environmentally friendly formulation design.
September 2024 in “Journal of Cosmetic Dermatology” This study found that the topical application of DA-OTC-002, a combination of synephrine and tyramine hydrochloride, significantly reduced immediate hair shedding in women by 62.5% compared to a placebo, without any observed adverse effects.