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This review discusses the role of acyl-CoA binding protein (ACBP) in the epidermal barrier, noting that its disruption in mice is linked to skin and fur abnormalities; it reports no new clinical results.

This study found that the acyl-CoA binding protein is essential for the production of very long chain free fatty acids in the stratum corneum and maintaining normal epidermal barrier function in mice.

This study observed that topical application of palmitate or oleate accelerated the onset of the hair growth phase in mice, whereas glycolysis end product lactate delayed it, suggesting metabolic regulation as a promising approach for influencing hair growth.

In this study, it was observed that NIPAL4 mutations linked to autosomal recessive congenital ichthyosis lead to abnormal skin barrier function due to cytotoxic effects disrupting lipid structure and organization, which topical treatments only partially ameliorated.

This review explores the role of fatty acids and bioactive lipid mediators in skin health and suggests targeting this metabolic network to control inflammation and improve skin conditions, but it reports no new findings.