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research Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells

28 citations , July 2021 in “Pharmaceutics”

This study found that Morus alba root extract activates β-catenin in hair follicle dermal papilla cells, promoting the transition to the anagen phase and enhancing hair growth factor secretion.

research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

November 2013 in “Institutional Repositories DataBase (IRDB)”

In this study, γ-ray exposure in mice decreased hair follicle density and pigmentation, suggesting damage to stem cells affecting hair follicle regeneration.

Patient-Reported Hair Loss and Its Impacts as Measured by the Alopecia Areata Patient Priority Outcomes Instrument in Patients Treated with Ritlecitinib: The Allegro Phase 2b/3 Randomized Clinical Trial

research Patient-Reported Hair Loss and Its Impacts as Measured by the Alopecia Areata Patient Priority Outcomes Instrument in Patients Treated with Ritlecitinib: The ALLEGRO Phase 2b/3 Randomized Clinical Trial

4 citations , October 2024 in “American Journal of Clinical Dermatology”

This study found that ritlecitinib improved patient-reported outcomes related to hair growth in individuals with alopecia areata, with some experiencing clinically meaningful hair regrowth, although changes in emotional symptoms and activity limitations were minimal and similar across treatment groups.

Developing Patient-Reported Outcome Measure for Hair and Skin Disorders

research A qualitative phase I study protocol on developing patient-reported outcome measure for hair, scalp, eyebrows, eyelashes, and beard-related skin disorders

August 2022 in “medRxiv (Cold Spring Harbor Laboratory)”

This protocol outlines a study aiming to develop a universal patient-reported outcome measure for various hair disorders through qualitative interviews, with no new clinical results reported yet.

research Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog

231 citations , October 1999 in “Journal of Clinical Investigation”

This study found that administering an adenovirus vector to increase Sonic hedgehog gene expression in mouse skin accelerated the transition of hair follicles into the growth phase, promoting hair growth.

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Community Join

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community PP405 Hair Loss Drug: Phase 1 Human Results & Biopsy Insights

213 upvotes 1 year ago

PP405 is a potential hair loss treatment undergoing trials, with discussions on its effectiveness and comparison to existing treatments like finasteride and minoxidil. There is skepticism about its status as a cure, with hopes for future advancements in genetic treatments like CRISPR.

community In my acceptance phase: hair concealers

5 upvotes 1 week ago

A 34-year-old woman is seeking effective hair concealers for thinning hair, having tried various medications like spironolactone and oral minoxidil without success. Recommendations include Boldify hairline powder and products like Hairo or Kerablend.

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Learn

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learn Hair Transplant

How long does a hair transplant procedure take? A hair transplant procedure typically takes 4 to 8 hours.

learn Fluridil

How long does it take to see results with Fluridil in progressive hair loss? No published study measures how long fluridil takes to show a visible change; the single double-blind trial (43 men, 2% fluridil) reported a rise in the proportion of hairs in the growth phase at three and nine months, and community reports describe stabilization rather than regrowth.

learn Follistatin

Are there any clinical studies supporting follistatin as a hair loss treatment? There is no controlled human trial showing follistatin treats hair loss; the published work is mouse and laboratory biology on the activin/follistatin signalling system, plus one small 2011 phase 1 injection study of a combination product, so follistatin remains experimental and unapproved.

learn TDM-105795

How is TDM-105795 used in hair-related products, and is it being explored as a topical treatment, an oral option, or both? TDM-105795 is not sold in any hair product — it is an unapproved experimental compound. The public trial registry shows it has been studied only as a topical scalp solution, in three completed company trials (the largest a 71-participant, 16-week Phase 2); no oral programme is registered, and no peer-reviewed publication exists.

learn Platelet-Rich Plasma

What is Platelet-Derived Growth Factor Beta Polypeptide, and how does it help stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Adenosine

nucleoside used for hair regrowth stimulant properties

learn Latanoprost

glaucoma medication with hair follicle stimulant effects

learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

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