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      learn Microneedling

      technique to create small wounds in skin to activate collagen production and hair growth

      learn Osteopontin

      signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

      learn PP405

      mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

      learn Adenosine

      nucleoside used for hair regrowth stimulant properties

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      community Anyone here who stopped microneedling and maintained or lost the gains?

      in Microneedling  9 upvotes 7 months ago
      Microneedling's long-term effects on hair loss are uncertain, with concerns about scarring and the need for continued use of minoxidil and finasteride to maintain gains. Finasteride does not sustain minoxidil-regrown hair without ongoing minoxidil use, and microneedling alone shows limited evidence of effectiveness.

      community How true is the statement: dead follicles don't grow back?

      in Research/Science  107 upvotes 8 months ago
      Hair follicles usually go dormant rather than die, and treatments like finasteride, minoxidil, and hormone therapy can sometimes reactivate them, though results vary. Complete regrowth is rare, especially in long-term bald areas, but some individuals see significant improvement with these treatments.

      community Can we get a reality check on PP405?

      in Research/Science  76 upvotes 3 weeks ago
      PP405 is a promising hair loss treatment that may outperform minoxidil and finasteride by reviving dormant follicles and promoting significant regrowth. Results from ongoing trials are awaited, with a potential market release between 2028-2030.