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research New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP₃‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75^NTRand TrkA) inex vivohuman male androgenetic scalp hair follicles

12 citations , April 2020 in “British Journal of Dermatology”

In this study, researchers found that caffeine can counteract stress-induced damage in ex vivo human androgenetic alopecia hair follicles, suggesting it may help prevent stress-related hair loss.

research New idea for hair transplantation to preserve more donor hair follicles

3 citations , May 2019 in “Medical Hypotheses”

This article discusses the potential of using vitrified hair follicles from younger men with a family history of male pattern baldness to increase donor availability for future hair transplantation, and reports no clinical results.

research New frontiers in human hair follicle (neuro‐)endocrinology

August 2006 in “Experimental dermatology”

This study suggests that human scalp hair follicles express erythropoietin and its receptor, up-regulating receptor expression under hypoxic conditions, and may mimic another hypothalamus–pituitary axis equivalent involving the TRH-TSH system.

research New technologies for hair follicle growth and regeneration: comparison between different commercial products contain exosomes

November 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that exosomes derived from bovine colostrum, compared to those from human stem cells, significantly increased hair follicle growth and regeneration in vitro.

research A new path in defining light parameters for hair growth: Discovery and modulation of photoreceptors in human hair follicle

70 citations , April 2017 in “Lasers in surgery and medicine”

This study found that blue light at a wavelength of 453 nm promoted hair growth ex vivo, potentially through interacting with OPN3 receptors in human hair follicles.

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Community Join

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community Is there hope for creating new hair follicles?

6 upvotes 3 weeks ago

Creating new hair follicles is unlikely in the next 10-20 years, with current treatments focusing on stimulating existing follicles. Experimental treatments like ky19382 are being tested, but reliable solutions are not yet available.

community Are these new follicle?

in Finasteride 58 upvotes 1 year ago

The user is questioning if black points on their scalp are new hair follicles. They are using finasteride and minoxidil for hair growth.

community Riken develops new method for culturing hair follicles

41 upvotes 8 years ago

A new stem cell method for culturing hair follicles is being developed as an alternative to Minoxidil, finasteride, and RU58841. There are concerns about its cost and accessibility despite plans for commercialization.

community Update about Hair Follicle Glucose Metabolism: New Clinical Data Collection with Ex-President Of American Board Of Hair Restoration Surgery.

39 upvotes 2 years ago

David Barreto shared that a London-based research group is conducting a 12-month trial for a new nutraceutical treatment for pattern hair loss, designed with Dr. Carlos Puig. The trial aims to provide robust data, with results expected in 1-2 years, potentially representing a significant advancement since finasteride’s introduction in 1997.

community New Study: PP405, developed by Pelage Pharmaceuticals, can reactivate dormant hair follicle stem cells and stimulate natural hair growth by 20%

843 upvotes 1 year ago

PP405, developed by Pelage Pharmaceuticals, can reactivate dormant hair follicle stem cells and increase hair growth by 20% in eight weeks, unlike minoxidil or finasteride. However, skepticism remains about its effectiveness and availability, with concerns about funding and the timeline for broader access.

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Learn

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learn Ecklonia Cava

Can Ecklonia Cava reactivate dormant hair follicles and support new growth? No human study has tested whether Ecklonia cava reactivates hair follicles; the evidence comes from cultured cells, cultured follicles and mice.

learn Scalp Micropigmentation

Will scalp micropigmentation grow my hair back? Scalp micropigmentation does not grow hair back; it only enhances appearance.
Does scalp micropigmentation look natural? Scalp micropigmentation can look natural if performed by a skilled practitioner.

learn Melatonin

Does melatonin only prevent hair loss or also help it grow new hair? Evidence is weak. One small trial in 40 women found a higher share of growing-phase hairs in some groups using topical melatonin, and no study shows it grows new hair follicles.

learn Platelet-Rich Plasma

What is platelet-derived growth factor beta polypeptide (PDGF-BB), and does it stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.