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GlossaryNerve Regeneration

process where damaged neurons repair and restore their function

Nerve regeneration, also known as nerve repair or neural regeneration, is the process by which damaged nerve cells (neurons) repair themselves and restore their function. This involves the regrowth of axons, the long thread-like parts of neurons, and the re-establishment of connections with other neurons or target tissues. While peripheral nerves have some capacity for regeneration, central nervous system nerves (like those in the brain and spinal cord) have limited ability to heal, making research in this area crucial for treating injuries and neurodegenerative diseases.

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Optogenetically Controlled TrkA Activity Improves the Regenerative Capacity of Hair-Follicle-Derived Stem Cells to Differentiate into Neurons and Glia

research Optogenetically Controlled TrkA Activity Improves the Regenerative Capacity of Hair-Follicle-Derived Stem Cells to Differentiate into Neurons and Glia

6 citations, September 2020 in “Advanced Biology”

The study demonstrated that hair-follicle-derived stem cells (HSCs) from the mouse vibrissa hair follicle could differentiate into neuronal and glial cells, with the TrkA receptor playing a crucial role in this process. By introducing the OptoTrkA system, which activates TrkA via blue-light illumination, researchers found that TrkA signaling enhanced the proliferation, migration, and differentiation of HSCs into neural cells. The ability to precisely control TrkA activity with optogenetics suggested a promising strategy for neuron regeneration and potential clinical applications in cell-transplantation therapy.

research A Molecular Wound Response Program Associated With Regeneration Initiation in Planarians

212 citations, May 2012 in “Genes & Development”

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

research Epidermal Stem Cells: An Update on Their Potential in Regenerative Medicine

9 citations, March 2013 in “Expert opinion on biological therapy”

Epidermal stem cells have potential for personalized regenerative medicine but need careful handling to avoid cancer.

research Chapter 14: Low-Level Laser Therapy and Stem Cells

August 2016

Low-level laser therapy may help stem cells grow and function better, aiding in healing and tissue repair.

research Therapeutic Potential of Hair Follicle-Derived Stem Cell Intranasal Transplantation in a Rat Model of Ischemic Stroke

8 citations, July 2022 in “BMC neuroscience”

Transplanted hair follicle stem cells improved brain function and reduced damage after a stroke in rats.

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community Verteporfin mixing solute for transplants

in Treatment 12 upvotes 9 months ago

Doctors are testing verteporfin topically for healing and potential regeneration after transplants. The user is asking how it is formulated for topical use, such as if it's mixed with a carrier gel.

community Completely defeated after trying so hard with topical finasteride.

in Finasteride/Dutasteride 24 upvotes 1 year ago

A user who has tried multiple treatments for hair loss, including oral and topical finasteride and liposomal finasteride, but experienced severe side effects in each case; the user is considering trying RU58841 or aromatise inhibitors as alternatives.

community Has redensyl, procapil and baicapil worked for anyone?

in Research/Science 14 upvotes 2 years ago

Exploring treatments for hair loss, such as finasteride, minoxidil, RPB (an unknown acronym), vitamin D levels, and derma rolling.

community I think I’m on to something

22 upvotes 5 years ago

The user shared their personal experience with hair loss, hormone imbalances, and treatments including testosterone boosters, natural estrogen blockers, and DHEA. They suggest that low-dose finasteride and natural hormone therapy could reduce hair loss with fewer side effects.

community Am I taking out too much foam for a dose? Rogaine Minoxidil

in Minoxidil 1 year ago

This conversation discusses the topical application of Minoxidil, with various users providing advice on how to accurately measure a dose and keep it from melting too quickly. Others have shared their experiences using oral finasteride for hair loss treatments.

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