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Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State

research Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State

31 citations , September 2013 in “Stem Cells”

Smad1 and Smad5 are essential for hair follicle development and stem cell sleepiness.

research Conditional Epidermal Expression of TGFβ1 Blocks Neonatal Lethality but Causes a Reversible Hyperplasia and Alopecia

103 citations , July 2001 in “Proceedings of the National Academy of Sciences”

TGFβ1 expression in skin causes hair loss and skin thickening, but these effects are reversible.

research Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge

387 citations , November 2003 in “Journal of Investigative Dermatology”

The K15 promoter effectively targets stem cells in the hair follicle bulge.

research Biological Significance of FoxN1 Gain-of-Function Mutations During T and B Lymphopoiesis in Juvenile Mice

16 citations , October 2014 in “Cell death and disease”

FoxN1 overexpression in young mice harms immune cell and skin development.

research The Importance of Basonuclin 2 in Adult Mice and Its Relation to Basonuclin 1

14 citations , March 2016 in “Mechanisms of Development”

Basonuclin 2 is vital for the development of facial bones, hair follicles, and male germ cells in adult mice, and its absence can lead to dwarfism and abnormal follicles.

View more "neonatal lethality" in research →

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community 1 year fin 1mg and minox. can see some density reclaimed

in Update 562 upvotes 4 years ago

User shared 1-year progress using finasteride 1mg and minoxidil, regaining hair density. Others praised the improvement and asked about side effects and additional treatments.

community Doctor won’t put me on fin or dut until my wife gives birth. Is this normal?

in Finasteride/Dutasteride 10 upvotes 1 year ago

A doctor advised against using finasteride or dutasteride during pregnancy. The user continues with oral and topical minoxidil, microneedling, tretinoin, Nizoral, and pyrilutamide.

community My Theory Of Androgenic Alopecia

in Research/Science 19 upvotes 3 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.