8 citations
,
December 2015 in “Daehan han'yi hag'hoeji/Journal of Korean medicine” This study found that transtherapy, a treatment using Korean medicine, significantly improved acne scars, reducing the scarring grade from an average of 3.5 to 1.5 in moderate and severe cases.
2 citations
,
July 2019 in “Digital Showcase Research, Scholarship, & Creative Works (University of Lynchburg)” This article reviews the use of isotretinoin for acne treatment and its controversial association with depression and suicide, noting limited evidence for a direct link.
18 citations
,
August 2011 in “Clinical Drug Investigation” This study found that a combination of low-dose isotretinoin and oral azithromycin pulse effectively treats severe acne with an acceptable side effect profile and relatively low relapse rates.
10 citations
,
January 2017 in “Dermatology Online Journal” This review found that metformin was an effective adjunct therapy for treating moderate-to-severe acne vulgaris in patients without polycystic ovary syndrome or androgen excess.
November 2025 in “Journal of Multidisciplinary Healthcare” This study found that combining fire needle therapy with DHT treatment over eight weeks improved lesion severity, scar symptoms, quality of life, and reduced serum inflammatory cytokine levels in patients with moderate-to-severe acne vulgaris compared to using DHT alone.
