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This case report highlights a rare instance of syphilitic alopecia and ocular syphilis in an immunocompetent, HIV-negative woman, showing that syphilis-directed treatment led to symptom reversal, emphasizing the need to consider syphilis in the differential diagnosis for atypical alopecia.

This meta-analysis found that the combination of topical minoxidil-finasteride was more effective than minoxidil alone in improving hair density, hair diameter, and global photographic assessment for male androgenetic alopecia, though larger standardized trials are needed to confirm long-term outcomes.

In this study, a 38-year-old male with syphilis-related mixed pattern alopecia showed marked hair regrowth and resolution of postauricular lymphadenopathy after treatment with benzathine penicillin, suggesting that lymph node and hair examinations, along with trichoscopy, can aid in the diagnosis of alopecia syphilitica.

This review outlines the classification, histopathologic presentation, and pathogenetic concepts of scarring and nonscarring alopecias, reporting no new clinical results and emphasizing the need for clinicopathologic correlation.

The authors concluded that trichoscopic examination can be useful for diagnosing syphilitic alopecia in patients with idiopathic alopecia, though the findings are nonspecific and further studies are needed.