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    GlossaryHair Follicle Miniaturization (miniaturization)

    hair follicles shrink, producing thinner and shorter hair strands

    Hair Follicle Miniaturization is a process where hair follicles gradually shrink, producing thinner and shorter hair strands over time. This phenomenon is commonly associated with androgenetic alopecia (pattern baldness) and can eventually lead to the cessation of hair growth in the affected follicles.

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      learn Alfatradiol

      a synthetic estrogen used topically as an anti-androgen

      learn Fluridil

      a topical anti-androgen with less systemic involvement

      learn Clascoterone

      a novel topical treatment that inhibits DHT on androgen receptors

      learn Osteopontin

      signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

      learn Minoxidil

      An essential vasodilator with some anti-androgenic effects, has excellent safety record

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      community Testosterone in Reference Range Doesn't Cause Hair Loss

      in Research/Science  51 upvotes 1 year ago
      Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

      community 5+ year users, what has your experience been on fin and dut?

      in Chat  30 upvotes 2 weeks ago
      Users discussed their experiences with hair loss treatments, primarily finasteride (Fin) and dutasteride (Dut), often combined with minoxidil (Min) and derma rolling. Many reported mixed results, with some seeing slowed hair loss and others experiencing side effects or minimal improvement.

      community GT20029 and PP405 the new fin and min that we been waiting for ?

      in Chat  36 upvotes 1 month ago
      PP405 and GT20029 are new hair loss treatments with different mechanisms from traditional options like Minoxidil and Finasteride. PP405 targets hair follicle stem cells to reactivate growth, while GT20029 works as an androgen receptor deleter, both requiring ongoing use for effectiveness.