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Did you mean Microphthalmia-associated transcription factor?

GlossaryMicrophthalmia-associated transcription factor

regulates genes for pigment production in skin, hair, and eyes

Microphthalmia-associated transcription factor (MITF) is a protein that plays a crucial role in the development and function of various cell types, including melanocytes, which are responsible for producing the pigment melanin in the skin, hair, and eyes. It regulates the expression of genes involved in cell growth, differentiation, and survival, and mutations in the MITF gene can lead to conditions like Waardenburg syndrome and certain types of albinism.

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research Bone Morphogenetic Protein Signaling Controls Hair Pigmentation Through Cross-Talk With the Melanocortin Receptor-1 Pathway

70 citations , December 2004 in “Proceedings of the National Academy of Sciences”

BMP signaling affects hair color by interacting with the MC-1R pathway.

research Melanocytes and Vitiligo and Hair Graying

1 citations , January 2014 in “Elsevier eBooks”

Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.

research The Complex Relationship Between TFEB Transcription Factor Phosphorylation and Subcellular Localization

344 citations , May 2018 in “EMBO journal”

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

research Tyrosine Kinase Inhibition and Grey Hair

59 citations , March 2003 in “The Lancet”

Imatinib can repigment grey hair, while SU11428 can cause temporary hair depigmentation.

research Anti-Melanogenic And Anti-Oxidative Effects Of Nostoc Verrucosum Extracts

6 citations , February 2023 in “Cosmetics”

Nostoc verrucosum extracts may help reduce melanin production and have antioxidant properties.

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