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      Mechanical Forces in Skin Disorders

      research Mechanical forces in skin disorders

      65 citations , March 2018 in “Journal of Dermatological Science”
      This review discusses the role of mechanical forces in skin homeostasis and disease development, including their impact on conditions like keloids, androgenetic alopecia, and acral melanoma, and reports no clinical results; the authors propose modifying these forces as a potential therapeutic strategy.
      Skin Aging as a Mechanical Phenomenon: The Main Weak Links

      research Skin aging as a mechanical phenomenon: The main weak links

      41 citations , May 2018 in “Nutrition and healthy aging”
      This study suggests that age-related changes in skin elasticity reduce its stability against wrinkling, and anti-aging strategies should focus on addressing elastic mismatches between skin layers.
      Insights on the Mechanical Behavior of Keratin Fibrils

      research Insights on the mechanical behavior of keratin fibrils

      13 citations , May 2016 in “International journal of biological macromolecules”
      This study demonstrated that molecular dynamics simulations of keratin could effectively model the mechanical properties of hair, aligning well with experimental data, especially when conducted in vacuum conditions.

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      community Mechanism of action of alfatradiol (17 alpha estradiol)

       5 upvotes 2 years ago
      The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

      community Mechanism of Action these drugs re-grow hair?

       2 upvotes 2 years ago
      Minoxidil, finasteride, and RU58841 promote hair growth by different mechanisms, with minoxidil and prostaglandin E1 being specifically mentioned. Corticosteroids can also cause hair growth.

      community PP405 mechanism question - looking for discussion

       7 upvotes 5 months ago
      PP405 may promote short-term hair growth by pushing follicles into the growth phase, but concerns exist about long-term effects due to lack of rest phases. Users discuss various treatments like finasteride, minoxidil, spironolactone, alfatradiol, and investigational drugs like KX-826 and GT20029 for hair maintenance and regrowth.

      community The mechanism of androgenic alopecia

       36 upvotes 11 months ago
      DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

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