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GlossaryMAPK pathway (MAPK cascade)

crucial cell signaling mechanism regulating growth, division, and stress response

The MAPK pathway, or Mitogen-Activated Protein Kinase pathway, is a crucial signaling mechanism in cells that helps regulate various activities such as growth, division, and response to stress. It involves a series of proteins that communicate signals from the cell surface to the DNA in the nucleus, ultimately influencing gene expression and cellular behavior. This pathway is significant in many biological processes and is often studied in the context of diseases like cancer and conditions affecting hair growth, such as alopecia.

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research A Computationally Inferred Regulatory Heart Aging Model Including Post-Transcriptional Regulations

1 citations, December 2016

Researchers created a model to understand heart aging, highlighting key genes and pathways, and suggesting miR-208a as a potential heart attack biomarker.

Phosphatidic Acid Has Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells

research Phosphatidic Acid Has Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells

46 citations, August 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

Phosphatidic acid may help hair grow by affecting cell growth pathways.

research Procyanidin Oligomers Counteract TGF-β1- and TGF-β2-Induced Apoptosis in Hair Epithelial Cells: An Insight into Their Mechanisms

14 citations, January 2006 in “Skin pharmacology and physiology”

Procyanidin compounds from apples and barley promote hair growth and prevent hair cell death.

research Overexpression of Alfalfa SIMK Promotes Root Hair Growth, Nodule Clustering, and Shoot Biomass Production

11 citations, October 2020 in “Plant biotechnology journal”

Overexpressing SIMK in alfalfa boosts root hair growth, nodule clustering, and shoot biomass.

research Epimedium Brevicornum Maxim Extract Enhances Melanin Biosynthesis and Melanosome Biogenesis/Transfer

6 citations, September 2022 in “Frontiers in pharmacology”

Epimedium extract helps increase skin pigmentation and could be a new treatment for conditions with reduced pigmentation.

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community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 120 upvotes 7 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

in Research/Science 13 upvotes 7 months ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.