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research A Novel Approach Against Male Pattern Hair Loss With Topical Dimethylglycine Sodium Salt (DMG‐Na) and Caffeine: Efficacy of a 24‐Week, Double‐Blind, Randomized, Placebo‐Controlled Trial

August 2025 in “Journal of Cosmetic Dermatology”

In this study, a DMG-Na and caffeine-containing shampoo significantly reduced hair loss and increased hair density in men with male pattern hair loss over 6 months, compared to a placebo, without adverse effects.

research Amazonian peppers as new ingredients against male androgen alopecia

September 2022 in “Zenodo (CERN European Organization for Nuclear Research)”

In this study, Amazonian pepper extracts showed potential as an ingredient for alopecia treatment due to their promising chemical profile, low cytotoxicity, and compatibility with shampoo formulations.

research Comparative efficacy of topical finasteride (0.25%) in combination with minoxidil (5%) against 5% minoxidil or 0.25% finasteride alone in male androgenetic alopecia: A pilot, randomized open-label study

March 2023 in “International Journal of Trichology”

This study found that a combination of topical 5% minoxidil and 0.25% finasteride was more effective at improving hair density and satisfaction in men with androgenetic alopecia than either treatment alone over 24 weeks.

research Safety and biopsy outcomes of a topical treatment (SM04554) for male androgenetic alopecia (AGA): Results from a phase 2, multicenter, randomized, double-blind, vehicle-controlled trial

1 citations , June 2017 in “Journal of The American Academy of Dermatology”

Topical treatment SM04554 safely promotes hair growth in male baldness.

research The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats

14 citations , March 2018 in “Translational Stroke Research”

In this animal study, researchers found that finasteride may offer neuroprotective benefits as a post-ischemic treatment for strokes in aged male rats, suggesting its potential as a therapeutic agent in this context.

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community AGA/male pattern baldness and loss of hair in the past 6months

52 upvotes 7 months ago

A 25-year-old male experienced significant hair loss due to telogen effluvium and androgenetic alopecia. He began using finasteride, minoxidil, and vitamins, seeing some regrowth but remains worried about hair density.

community KX-826 Phase II Results Just Dropped (Male AGA) – Key Takeaways

15 upvotes 1 year ago

KX-826 Phase II results show that a 0.5% concentration performs better than 1% for treating male pattern baldness. Concerns about receptor upregulation from long-term DHT antagonism were mentioned.

community Male 23 kya topical minoxidil 18 mahine tak istemaal karne ke baad result nahi mila to mujhe oral minoxidil istemaal karna chahiye agar karna chahiye to kitna mg se chaalu kare

4 weeks ago

A user is considering switching from topical to oral minoxidil after 18 months without results, with suggestions to start at 1.25 mg twice daily. Another user shared success with 0.5 mg finasteride nightly and 1.25 mg minoxidil in the morning, suggesting adjusting doses based on results.

community [13-Year Hair Loss Journey – Reached Norwood 7, Trying Again in 2025 (Male, 32, Vietnam)]

245 upvotes 11 months ago

A 32-year-old man from Vietnam, at Norwood 7 hair loss, is using Minoxidil, Finasteride, rosemary oil, NMN, and CoQ10 to regrow hair. Despite minor improvements, alternatives like hair systems or accepting baldness are suggested due to advanced hair loss.

community 31M with AGA + seb derm: worried I’m late to start finasteride — start now or control scalp first?

in Basic Questions 203 upvotes 2 months ago

A 31-year-old male with androgenetic alopecia and seborrheic dermatitis is considering starting finasteride and minoxidil for hair loss, while also using ketoconazole and salicylic acid shampoos for scalp treatment. He is concerned about the timing of starting finasteride and potential side effects, and seeks advice on whether to prioritize scalp health or begin hair loss treatments simultaneously.

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