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GlossaryAndrogenetic Alopecia (Male AGA)

genetic hair loss influenced by androgens, often hereditary

Androgenetic Alopecia, commonly known as Male Pattern Baldness or Female Pattern Baldness, is a genetic condition characterized by progressive hair thinning and loss. It is influenced by androgens (male hormones) and typically follows a recognizable pattern, such as a receding hairline in men and diffuse thinning on the crown in women. This condition is the most common cause of hair loss, affecting both genders, and is often hereditary.

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Comparative Efficacy of Topical Finasteride (0.25%) in Combination With Minoxidil (5%) Against 5% Minoxidil or 0.25% Finasteride Alone in Male Androgenetic Alopecia: A Pilot, Randomized Open-Label Study

research Comparative Efficacy of Topical Finasteride (0.25%) in Combination With Minoxidil (5%) Against 5% Minoxidil or 0.25% Finasteride Alone in Male Androgenetic Alopecia: A Pilot, Randomized Open-Label Study

March 2023 in “International Journal of Trichology”

Using both minoxidil and finasteride together is more effective for male hair loss than using either one alone.

Safety and Biopsy Outcomes of a Topical Treatment (SM04554) for Male Androgenetic Alopecia: Results from a Phase 2, Multicenter, Randomized, Double-Blind, Vehicle-Controlled Trial

research Safety and Biopsy Outcomes of a Topical Treatment (SM04554) for Male Androgenetic Alopecia: Results from a Phase 2, Multicenter, Randomized, Double-Blind, Vehicle-Controlled Trial

1 citations, June 2017 in “Journal of The American Academy of Dermatology”

Topical treatment SM04554 safely promotes hair growth in male baldness.

research Evaluation of Serum Ischemia Modified Albumin Level in Male Patients with Androgenetic Alopecia

1 citations, February 2021 in “Benha Journal of Applied Sciences”

Higher IMA levels in male AGA patients, especially if obese, may link AGA to metabolic and heart issues.

research Serum Progranulin and Insulin Resistance Evaluation in Male Androgenetic Alopecia Patients

March 2022 in “Benha Journal of Applied Sciences”

AGA patients have higher insulin resistance and serum progranulin levels, suggesting a link to metabolic issues.

research Investigation of Plasma Thiol/Disulfide Balance in Male Patients with Androgenetic Alopecia

December 2021 in “Journal of Cosmetic Dermatology”

Thiol/disulfide balance is normal in male AGA patients but shifts towards oxidative stress with emotional stress and low vitamin D.

research Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

9 citations, January 2019 in “American Journal of Dermatopathology”

DKK-1 gene linked to hair loss in AGA and AA patients; more research needed for potential therapy.

research Global Expression Profile and Genome Methylation Signatures in Male Patients with Androgenetic Alopecia

2 citations, December 2019 in “Journal of The European Academy of Dermatology and Venereology”

Differences in gene expression and methylation patterns found in AGA patients suggest potential targets for future treatments.

research LB808: A Humanized Mouse Model of Androgenetic Alopecia (AGA) Shows That Platelet-Rich Plasma (PRP) Stimulates Hair Regrowth

August 2021 in “Journal of Investigative Dermatology”

Platelet-rich plasma (PRP) helps regrow hair in male pattern baldness.

research Finasteride, 1 Mg Daily Administration on Male Androgenetic Alopecia in Different Age Groups: 10-Year Follow-Up

44 citations, July 2011 in “Dermatologic Therapy”

Finasteride effectively increases hair growth in men with AGA, works better for those over 30, and may cause some side effects.

research Is Minoxidil Efficacious and Safe for the Treatment of Androgenetic Alopecia in Men, and If So, What Is the Optimal Strength and Means of Delivery?

January 2014

5% minoxidil is safe and effective for treating male hair loss.

research Female Androgenetic Alopecia: A Separate Entity

50 citations, July 2000 in “Dermatologic Surgery”

Female and male AGA are different diseases.

research Platelet-Rich Plasma Injections in the Treatment of Male Androgenetic Alopecia: A Randomized Placebo-Controlled Crossover Study

9 citations, September 2019 in “Journal of Cosmetic Dermatology”

PRP injections improve hair density in male hair loss.

research Understanding Patient and Physician Perceptions of Male Androgenetic Alopecia Treatments in Asia-Pacific and Latin America

5 citations, March 2017 in “Journal of Dermatology”

Patients and doctors find current hair loss treatments unsatisfying and believe involving patients in decisions improves results.

Autologous Concentrated Growth Factors Combined With Topical Minoxidil for the Treatment of Male Androgenetic Alopecia: A Randomized Controlled Clinical Trial

research Autologous Concentrated Growth Factors Combined With Topical Minoxidil for the Treatment of Male Androgenetic Alopecia: A Randomized Controlled Clinical Trial

4 citations, August 2020 in “Facial plastic surgery & aesthetic medicine”

Combining growth factors with minoxidil improves hair growth more than minoxidil alone.

Assessing the Efficacy and Quality of Life Improvements of Botulinum Toxin Type A with Topical Minoxidil Versus Topical Minoxidil in Male Androgenetic Alopecia: A Randomized Controlled Trial

research Assessing the Efficacy and Quality of Life Improvements of Botulinum Toxin Type A with Topical Minoxidil Versus Topical Minoxidil in Male Androgenetic Alopecia: A Randomized Controlled Trial

August 2024 in “Archives of Dermatological Research”

Combining botulinum toxin type A with Minoxidil significantly improves hair growth and patient satisfaction in male hair loss.

research Comparative Study of the Effect of Topical Minoxidil 5% Versus Combined Fractional CO2 Laser and Topical Minoxidil 5% in the Treatment of Male Androgenetic Alopecia

January 2022 in “The Egyptian Journal of Hospital Medicine”

Combining fractional laser with minoxidil 5% is more effective for treating male hair loss than using minoxidil 5% alone.

research Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness?

57 citations, February 2014 in “Experimental Dermatology”

Prostaglandin D₂ might be targeted for new male pattern baldness treatments.

research Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us?

46 citations, February 2016 in “Experimental Dermatology”

Genes play a significant role in male-pattern baldness, and understanding them could lead to new treatments and insights into related health issues.

research Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects

41 citations, July 2009 in “International Journal of Trichology”

58% of men aged 30-50 have hair loss, with severity increasing with age.

Higher Body Mass Index Is Associated With Greater Severity of Alopecia in Men With Male-Pattern Androgenetic Alopecia in Taiwan: A Cross-Sectional Study

research Higher Body Mass Index Is Associated With Greater Severity of Alopecia in Men With Male-Pattern Androgenetic Alopecia in Taiwan: A Cross-Sectional Study

38 citations, November 2013 in “Journal of The American Academy of Dermatology”

Higher BMI links to worse hair loss in Taiwanese men.

research Male Pattern Androgenetic Alopecia in an Indian Context: A Perspective Study

28 citations, March 2007 in “Journal of The European Academy of Dermatology and Venereology”

At least 87% of Indian men experience hair loss, with type II being most common and severity increasing with age.

research Contrast Enhanced Phototrichogram Pinpoints Scalp Hair Changes in Androgen Sensitive Areas of Male Androgenetic Alopecia

22 citations, May 2002 in “Skin Research and Technology”

CE-PTG detects early hair follicle issues in balding areas, helping measure male hair loss.

research Investigation of Four Novel Male Androgenetic Alopecia Susceptibility Loci: No Association with Female Pattern Hair Loss

21 citations, December 2013 in “Archives of Dermatological Research”

No link found between new male baldness genes and female hair loss.

research Association Between Androgenetic Alopecia and Coronary Artery Disease in Young Male Patients

20 citations, January 2014 in “International Journal of Trichology”

Hair loss linked to heart disease in young men.

research Treatment of Male Androgenetic Alopecia with Topical Products Containing Serenoa Repens Extract

18 citations, May 2015 in “Australasian Journal of Dermatology”

Serenoa repens extract in topical products improves hair growth and appearance in male pattern baldness with mild side-effects.

Efficacy and Safety of a New 10% Topical Minoxidil Versus 5% Topical Minoxidil and Placebo in the Treatment of Male Androgenetic Alopecia: A Trichoscopic Evaluation

research Efficacy and Safety of a New 10% Topical Minoxidil Versus 5% Topical Minoxidil and Placebo in the Treatment of Male Androgenetic Alopecia: A Trichoscopic Evaluation

14 citations, August 2019 in “Journal of Dermatological Treatment”

10% minoxidil solution better promotes hair growth and reduces hair loss without significant side effects.

research Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial

11 citations, October 2021 in “Journal of The European Academy of Dermatology and Venereology”

Topical finasteride is an effective and safer treatment for male hair loss.

research Therapeutic Implications of Topical Cetirizine 1% in Treatment of Male Androgenetic Alopecia: A Case-Controlled Study

5 citations, January 2021 in “Journal of Cosmetic Dermatology”

Topical cetirizine 1% promotes hair growth in male androgenetic alopecia patients.

research Autologous Platelet-Rich Plasma as a Treatment for Male Androgenetic Alopecia: Study of 14 Cases

4 citations, January 2015 in “Journal of clinical & experimental dermatology research”

PRP injections may slightly improve hair density and count for male hair loss, but more research is needed.

research Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia

3 citations, November 2021 in “Frontiers in Medicine”

Advanced male pattern baldness affects the back of the scalp, reducing hair follicles.