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Sweat Glands Shrink Upward With Aging, Causing Dermal Layer Defects Leading to Loss of Skin Elasticity and Wrinkling - Establishment of 3D Imaging Method for Skin Appendages

research 250 Sweat glands shrink upward with aging, causing dermal layer defects that lead to loss of skin elasticity and wrinkling-establishment of 3D imaging method for skin appendages

September 2017 in “Journal of Investigative Dermatology”

This study found that their novel 3D-imaging method, ASAXA-μCT, identified shrinkage of sweat glands as a key factor in skin aging, which leads to dermal defects, decreased elasticity, and increased wrinkling and sagging.

research Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis

7 citations , February 2022 in “Stem cell reviews and reports”

This review discusses the heterogeneity and plasticity of epithelial stem cells in skin homeostasis, wound healing, and tumorigenesis, reporting no new results but emphasizing the need for further exploration of key regulatory mechanisms.

Skin Manifestations and Biophysical Properties in Patients With Morbid Obesity and Changes After Weight Loss: A Two-Year Prospective Study

research 393 Skin manifestations and biophysical properties in patients with morbid obesity and changes after weight loss: A two-year prospective study

April 2023 in “Journal of Investigative Dermatology”

In this study, bariatric surgery in patients with morbid obesity improved various skin conditions, although acute telogen effluvium was common, with notable reductions in facial sebum and skin elasticity changes.

research Injectable “Skin Boosters” in Aging Skin Rejuvenation: A Current Overview

22 citations , July 2024 in “Archives of Plastic Surgery”

This review detailed the types and mechanisms of injectable "skin boosters" and evaluated their effectiveness and safety for mitigating age-related skin changes, providing insight into their use in contemporary dermatological practice.

Skin Aging and Menopause: Implications for Treatment

research Skin Aging and Menopause

180 citations , January 2003 in “American Journal of Clinical Dermatology”

This article reviews the effects of menopause on skin aging and suggests that hormone replacement therapy may help reverse some of these changes.

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Community Join

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community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community A Decade on Hairloss Battle

9 upvotes 6 years ago

The post discusses a 10-year battle with hair loss using treatments like biotin, Rogaine, Dualgen 15% Minoxidil, dermaroller, and various skin care products. Despite some side effects, the user maintains a full head of hair and is considering a hair transplant in the future.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community What do you think about this? he says one of the causes of pattern hair loss is scars and it can be fixed

4 months ago

The conversation discusses hair loss treatments, focusing on insulin resistance, microneedling with topical melatonin, and stress reduction. Users express skepticism about the advice, preferring proven treatments like minoxidil and finasteride, while some mention alternative methods like dermal incisions and verteporfin for reducing fibrosis.

community So does oral minoxidil age your skin or not

43 upvotes 2 years ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

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Learn

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learn Epidermal Growth Factor

learn Scalp Micropigmentation

Can women get scalp micropigmentation? Yes, women can get scalp micropigmentation for hair loss or thinning.
Is scalp micropigmentation safe? Providers describe scalp micropigmentation as low-risk when a trained practitioner uses sterile single-use equipment, but that is a provider claim rather than a regulatory finding: pigment allergy, infection and colour change are documented risks of cosmetic tattooing.
Does scalp micropigmentation hurt? Scalp micropigmentation typically causes minimal discomfort, often described as light scratching.

learn Melatonin

Can melatonin cause side effects on the skin or hair? Melatonin may cause hair loss or thinning in some users, but evidence is limited.

learn Fluocinolone

Is Fluocinolone a treatment for hair loss itself or just for calming scalp irritation? Fluocinolone acetonide is a prescription corticosteroid approved for inflammatory skin conditions, not for hair loss; no published human trial has measured hair regrowth with it, so at most it may help indirectly by calming an inflamed scalp.

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Peppermint

herb and oil thought to stimulate skin and hair

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Clinics

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Experts

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SMP Specialist
Noelle Skin
Nice, France

Noelle Skin