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Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis

181 citations , January 2009 in “Nature Genetics”

In this study, researchers linked defects in U2HR, an inhibitory region in the HR gene, to Marie Unna hereditary hypotrichosis, suggesting a mechanism for controlling hair growth and addressing hair loss.

research Loss-of-Function Mutations in HOXC13 Cause Pure Hair and Nail Ectodermal Dysplasia

74 citations , October 2012 in “The American Journal of Human Genetics”

This study found that loss-of-function mutations in the HOXC13 gene cause autosomal-recessive pure hair and nail ectodermal dysplasia, emphasizing its role in hair and nail development.

research Losing Hair, Losing Points?: The Effects of Male Pattern Baldness on Social Impression Formation1

68 citations , February 1990 in “Journal of Applied Social Psychology”

This study found that men with common male pattern baldness received less favorable initial social perceptions, including lower ratings of physical attractiveness, than their nonbalding counterparts.

research Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis

51 citations , August 2013 in “The Journal of experimental medicine/The journal of experimental medicine”

This study found that Wnt secretion is important for maintaining skin homeostasis in mice, as Evi-deficient mice developed psoriasis-like skin lesions and had an imbalance in immune cell populations.

research Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles

47 citations , May 1995 in “Journal of Investigative Dermatology”

Hair follicles in people with alopecia have lower levels of a key blood vessel growth protein.

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Community Join

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community Losing Hair from Microneedling?

4 upvotes 5 days ago

Microneedling can cause hair shedding due to follicle puncturing, especially when using a 1mm depth. Users suggest using a dermastamp with a depth of 0.6-1mm and caution against home microneedling to avoid damaging hair follicles.

community Losing ground on 1.5 fin only, am i imagining it or is this lost ground?

7 upvotes 2 weeks ago

The user is experiencing hair thinning and is considering adding Minoxidil to their current finasteride treatment. Suggestions include using Minoxidil, possibly switching to Dutasteride, and considering microneedling and RU58841.

community Losing grounds? 6.5 month fin/min

7 upvotes 2 weeks ago

A 23-year-old male using topical minoxidil, finasteride, ketoconazole, and biotin for 6.5 months feels his hairline is worsening and considers switching to oral minoxidil due to poor response to topical treatment. Users suggest checking vitamin deficiencies, particularly vitamin D, and advise patience, as hair loss treatments can take time to show results.

community Losing ground ? Progress pictures over 2 years

17 upvotes 2 weeks ago

The user has been using oral finasteride since February 2025 and added oral minoxidil in March 2026, noticing significant regrowth but is concerned about recent hairline thinning, possibly due to a shedding phase. They are considering adding dutasteride and eventually getting a hair transplant for long-term density improvement.

community Losing ground after switching to DUT

14 upvotes 1 month ago

Switching from finasteride to dutasteride may lead to hair loss for some, with some users considering switching back to finasteride. Minoxidil, both oral and topical, is also used but results vary.

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Learn

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learn Baicapil

Losing hair from hormonal imbalance? Baicapil might block DHT without messing with your hormones. No published study shows that Baicapil blocks DHT — the only data on the ingredient itself is the manufacturer's own unpublished dossier, and the baicalin research behind the claim is cancer cell-line work in which the effect was explicitly independent of the androgen receptor.

learn Platelet-Rich Plasma

Are Platelet results permanent, or does hair loss return once treatment stops? Hair loss typically returns after stopping PRP treatment, as effects are not permanent.

learn Vitamin B12

How can you tell if your hair loss is related to low Vitamin B12 levels? Hair loss may indicate low Vitamin B12 if accompanied by fatigue and anemia symptoms.

learn Hair Transplant

What is shock loss after a hair transplant? Shock loss is temporary hair shedding after a transplant, usually resolving in a few months.
What is shock loss? Shock loss is temporary hair shedding after transplantation, usually resolving in 1-4 months.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn Cetirizine

popular antihistamine showing promise for hair loss as an anti-inflammatory and prostaglandin inhibitor

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

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Clinics

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Hair Transplant Surgeon
Dr. Daniela De Los Angeles Moncada Barrientos
San Jose, Costa Rica

Dr. Daniela De Los Angeles Moncada Barrientos