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community Studies on creatine where participants don’t go thru loading phase?

4 upvotes 3 years ago

Creatine use may increase hair shedding, with some users experiencing hair loss after a month of use, including a loading phase. Users are concerned about creatine's impact on hair despite using treatments like Minoxidil and finasteride.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

124 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community The second shed has been brutal (4 months and ongoing)

in Progress Pictures 44 upvotes 6 months ago

The user experienced significant hair regrowth using topical finasteride and minoxidil but faced a prolonged shedding phase, leading them to increase the finasteride dose and add oral dutasteride. Despite concerns about shedding, they remain hopeful for regrowth and are supplementing with Vitamin D.

community 2nd shed Update: Lost everything and still losing like crazy.

in Update 176 upvotes 1 year ago

The user experienced significant hair loss after initially successful treatment with minoxidil and finasteride, leading to a second shedding phase. They are considering switching to oral minoxidil for convenience and are advised to continue treatment despite the shedding, as regrowth is expected.

community Another follow up. 2 years and 7 months on Fin and Min. For the first time in years, I can grow my hair.

1046 upvotes 10 months ago

The user experienced significant hair regrowth using oral finasteride (1 mg) for 2 years and 7 months and topical minoxidil (5%) for about 13 years, with no side effects reported. The user noted many shedding phases but observed stronger hair regrowth each time, leading to increased confidence and positive feedback from others.

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Research

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research Long-Term Efficacy of Ritlecitinib up to Month 24 From the ALLEGRO Phase 2b/3 and Long-Term Phase 3 Clinical Studies in Alopecia Areata

6 citations , March 2024 in “SKIN The Journal of Cutaneous Medicine”

In this ongoing phase 3 study, ritlecitinib demonstrated sustained efficacy up to 24 months in patients aged 12 or older with alopecia areata, showing increased response rates with or without an initial loading dose and supporting its long-term use.

research Probiotic Bacteria Induce a ‘Glow of Health’

127 citations , January 2013 in “PLOS ONE”

This study found that feeding aged mice a probiotic yogurt induced changes leading to thicker, healthier fur, suggesting a bacteria-triggered interleukin-10-dependent mechanism that mimics signs of youth and reproductive fitness.

research Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

54 citations , May 2001 in “Journal of Investigative Dermatology”

This study suggests that increased putrescine levels may disrupt normal hair follicle development in transgenic mice, leading to hair loss and altered skin structure, yet these mice appear more resistant to skin tumorigenesis.

research Disorders of Hair Pigmentation

November 2021 in “CRC Press eBooks”

This review discusses the genetic and metabolic factors influencing hair pigmentation, as well as conditions leading to hypo- or depigmented hair, and reports no new experimental findings.

research L'idea di fenomeno fra Kant ed Husserl

January 2004 in “Giornale di Metafisica: revista bimestrale di filosofia”

This study suggests that increased Wnt signaling may promote excessive differentiation of melanocytes, leading to exhaustion of melanocyte stem cells and hair graying in aged mice.

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