In this study, a copper-deficient diet in rats led to a significant decrease in blood and liver copper levels without causing clinical symptoms, while hair leachable copper and bone copper remained unchanged.
January 2020 in “Journal of Clinical Biochemistry and Nutrition” This study observed that lower serum zinc levels in patients with chronic liver disease were linked to a higher prevalence of symptoms like dermatitis, taste disorder, and alopecia, suggesting these symptoms may be associated with zinc deficiency.
January 2013 in “Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai” This study found that Huoxue Bushen Mixture was effective in treating female pattern hair loss by improving symptom scores and altering serum hormone levels.
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September 2014 in “Diabetes” This study found that male 5αR1 knockout mice and obese Zucker rats treated with finasteride showed increased insulin resistance and hepatic steatosis, potentially implicating 5α-reductase activity in metabolic liver disease development.
October 2025 in “Journal of the Endocrine Society” The researchers reported that individuals with non-alcoholic fatty liver disease and nutritional deficiency often exhibit iron and estrogen deficiencies, which may contribute to liver cell stress and fibrosis.