Estrogen Deficiency in Patients with Reduced Fat Mass as a Cause of Non-Alcoholic Fatty Liver Disease

The study investigates the link between estrogen deficiency and non-alcoholic fatty liver disease (NAFLD) in patients with reduced fat mass, involving 20 participants aged 18 to 45. The research highlights that reduced nutrition leads to iron deficiency, which impairs steroidogenesis and results in low estrogen levels. Estrogen deficiency, a key factor in NAFLD, is associated with symptoms like hair loss, dry skin, and increased blood pressure. The study concludes that nutritional deficiency causing body and fat weight deficiency is a new diagnostic criterion for NAFLD, emphasizing the role of estrogens as hepatoprotectors.