September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”
This study found that zebrafish and stickleback fish use similar genetic programs for tooth regeneration, despite differences in their dental structures.
318 citations
,
January 2022 in “Signal Transduction and Targeted Therapy”
This study systematically reviews the Wnt/β-catenin signaling pathway, discussing its origin, composition, function, involvement in tumors and diseases, and the development of small-molecular compounds targeting this pathway for disease treatment.
In this study, researchers conducted whole-genome resequencing of eight sheep breeds to identify additional genes associated with wool fineness, revealing 269 genes in fine wool and 319 in coarse wool breeds that are linked to significant traits and pathways.
This study found that zebrafish and sticklebacks, despite differences in their tooth regeneration structures, share a similar genetic program during tooth regeneration, suggesting a conserved "successional dental epithelium" in vertebrates.
This study identified Lgr5 and Lgr6 as receptors expressed by small populations of stem cells in various adult organs, with Lgr5+ve cells forming long-lived organoids in certain mouse models.