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GlossaryLeydig cell hyperplasia

abnormal increase in testosterone-producing cells in the testes

Leydig cell hyperplasia is a condition where there is an abnormal increase in the number of Leydig cells, which are found in the testes and are responsible for producing testosterone. This can lead to hormonal imbalances and may be associated with symptoms such as testicular enlargement or changes in secondary sexual characteristics.

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research A Case Report of a Novel Homozygote Mutation Causing Severe Leydig Cell Hypoplasia: Insights into the Coexistence of Nonsense Mutation and Polymorphism in the Same LHCGR Gene Locus

November 2012 in “Experimental and Clinical Endocrinology & Diabetes”

A new genetic mutation causes severe Leydig cell hypoplasia, affecting sexual development.

research 46,XY DSD Due to Impaired Androgen Production

54 citations , April 2010 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

research Androgen Biosynthesis and Gene Defects

November 2014 in “Elsevier eBooks”

Gene mutations can cause problems in male genital development.

research Physiology of Male Gonadotropic Axis and Disorders of Sex Development

January 2017 in “Springer eBooks”

Understanding genes and hormones is crucial for managing male puberty and sex development disorders.

research The Laboratory in the Multidisciplinary Diagnosis of Differences or Disorders of Sex Development (DSD)

July 2021 in “Advances in laboratory medicine”

Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

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community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 1 year ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community FtM: "Aggressive Regemin - Recovery From Norwood-6.5" Minoxodil/Estradiol valerate/Spironolactone. (What will happen in the worst case if CIS male go this way for a year?)

in Progress Pictures 53 upvotes 4 years ago

User "Ant1pal" shares progress pictures of hair regrowth using Minoxidil, Estradiol valerate, and Spironolactone. Users discuss potential side effects and the possibility of localizing estrogen to hair follicles for better treatment.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 3 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.