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state where cells permanently stop dividing but remain metabolically active

Cellular senescence is a state in which cells stop dividing and enter a permanent state of growth arrest without dying. This process is a natural part of aging and acts as a defense mechanism against cancer, as it prevents damaged cells from proliferating. However, the accumulation of senescent cells over time can contribute to tissue dysfunction and age-related diseases.

Related Terms

• Aging
• Cell Cycle Arrest
• Telomere Shortening
• Senescence-Associated Secretory Phenotype (SASP)
• Apoptosis
• apoptosis
• telomere shortening
• oxidative stress
• Cell Line
• Cell Density