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    Glossary5α-reductase deficiency

    genetic condition impairing testosterone conversion to dihydrotestosterone (DHT)

    5α-reductase deficiency is a genetic condition where the body lacks sufficient levels of the enzyme 5α-reductase, which is crucial for converting testosterone into dihydrotestosterone (DHT). This deficiency can lead to atypical development of male genitalia in utero and can affect secondary sexual characteristics during puberty.

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