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Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells

research Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells

1 citations , August 2023 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

research The ATP Sensitive Potassium Channel (KATP) Is a Novel Target for Migraine Drug Development

13 citations , June 2023 in “Frontiers in Molecular Neuroscience”

Blocking the KATP channel may help treat migraines.

Immunohistochemical, Pharmacovigilance, and Omics Analyses Reveal the Involvement of ATP-Sensitive K+ Channel Subunits in Cancers: Role in Drug-Disease Interactions

research Immunohistochemical, Pharmacovigilance, and Omics Analyses Reveal the Involvement of ATP-Sensitive K+ Channel Subunits in Cancers: Role in Drug-Disease Interactions

3 citations , April 2023 in “Frontiers in Pharmacology”

ATP-sensitive K+ channel subunits, particularly Sur2A, play a significant role in various cancers.

research Katp Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema

18 citations , October 2020 in “Journal of Pharmacology and Experimental Therapeutics”

KATP channel openers may cause peripheral edema by reducing lymphatic contractions and flow.

research K ATP Channels and Cardiovascular Disease

144 citations , March 2013 in “Circulation Research”

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

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