This study identified significant differences in KIR gene profiles between SLE patients and controls, suggesting that specific KIR genes could serve as biomarkers for disease severity in Indian SLE patients.
February 2009 in “Journal of The American Academy of Dermatology” Certain immune system genes are linked to a higher risk of psoriasis and psoriatic arthritis, while others may offer protection.
March 2026 in “Nature Communications” In this study, researchers conducted a large genome-wide association meta-analysis and found 30 significant genetic loci linked to the risk of dermatophytosis, shedding light on the roles of keratin biology, skin barrier defects, immune dysfunction, and obesity in the disease.
February 2009 in “Journal of The American Academy of Dermatology” This study found that HLA-B*57 and HLA-Cw*06 were associated with increased risk of psoriasis vulgaris, while KIR2DL2 was more prevalent in controls, suggesting a protective effect.
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July 2023 in “Biomolecules” This study reports that some human cell surface HLA-I molecules (including HLA-B27) can appear without their usual peptide component, potentially altering immune interactions, influencing arthritis development in specific mice models, and exhibiting upregulation in certain cancer cells.