Association of Psoriasis and Psoriatic Arthritis with Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Gene Frequency: A Multiethnic Population Study

    February 2009 in “ Journal of The American Academy of Dermatology ”
    Image of study
    TLDR Certain immune system genes are linked to a higher risk of psoriasis and psoriatic arthritis, while others may offer protection.
    The study aimed to investigate the association between human leukocyte antigen (HLA) classes I and II and killer cell immunoglobulin-like receptor (KIR) genes with psoriasis vulgaris and psoriatic arthritis. Fifty-five patients with psoriasis vulgaris were evaluated and compared with 134 bone marrow donors as controls. The results showed that HLA-B*57 was present in 23.6% of patients and 7.5% of controls, and HLA-Cw*06 in 29.1% of patients and 16.4% of controls, indicating these alleles as risk factors for psoriasis. HLA-B*57 and HLA-Cw*18 were significantly associated with patients with arthritis. HLA-B*57 was also significantly present in patients with a history of erythroderma, hospital admission, and systemic treatment. The haplotype HLA-A*02 B*57 Cw*06 DQB1*03 DRB1*07 was the most common among patients. KIR2DL2 was found in 53.0% of controls and 29.1% of patients, suggesting a protective role. This study concluded that HLA-B*57 and HLA-Cw*06 are risk factors for psoriasis and psoriatic arthritis, while KIR2DL2 may offer protection. This was the first time HLA-Cw*18 and KIR2DL2 were associated with psoriasis. The study was supported by government funds from FAPERJ and Capes.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 96 results
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  862 upvotes 3 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 6 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community 4 years on finasteride and Minoxidil with great success. Ask me stuff!

      in Progress Pictures  950 upvotes 2 years ago
      . ummwhatsure: No it doesn't. I started losing my hair around 27/28. This user has had great success with a combination of finasteride and Minoxidil, taking 1 milligram of finasteride per day and applying Minoxidil twice daily for 4 years, starting when they were 31. They experienced some shedding in the first two years, but now have thicker, fuller hair than before.

      community No idea what's causing my hair thinning

      in Chat  2 upvotes 4 months ago
      The user is experiencing diffuse hair thinning despite using finasteride and oral minoxidil, with no hairline recession or bald spots. Suggestions include checking for telogen effluvium, considering a JAK inhibitor for potential autoimmune issues, and conducting further tests to rule out other causes.

      community What else is good. Besides the big 3.

      in Chat  34 upvotes 4 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

    Similar Research

    5 / 1000+ results