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Glossary Keratin 15

protein crucial for hair follicle stem cell regulation

Keratin 15 (K15) is a type of protein found in the hair follicles and skin, playing a crucial role in the structural integrity and function of these tissues. It is particularly important for the maintenance and regeneration of hair, as it is involved in the regulation of stem cells within the hair follicle, which are essential for hair growth and repair.

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Research

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research Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis

December 2025 in “The Journal of Cell Biology”

This study found that keratin 15 lacks the ability to sequester YAP1 in keratinocytes effectively, unlike keratin 14, and suggests that a higher K15:K14 ratio may promote a progenitor state and inhibit differentiation in epidermal keratinocytes.

research Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes

198 citations , March 1999 in “Journal of Investigative Dermatology”

This study found that keratin 15 expression is downregulated in hyperproliferative conditions like psoriasis and hypertrophic scars, suggesting it is not compatible with keratinocyte activation.

research Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes

90 citations , February 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that interleukin-1 directly induces the expression of keratin 6 in keratinocytes, which is a marker of activation and involved in inflammatory skin responses.

research Expression of the hair stem cell-specific keratin 15 in pilar tumors of the skin.

54 citations , September 1999 in “PubMed”

This study suggests that immunostaining for Keratin 15 may be a useful tool for differentiating between basal cell carcinoma and trichoepithelioma.

research Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino-Acid Composition and Repeat Structure

51 citations , January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identified a novel keratin-associated protein, KAP24.1, which is specifically expressed in the human scalp and located in the hair cuticle.

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Community Join

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community Additional supplements / peptides to maximize finasteride benefit

in Research/Science 3 upvotes 3 months ago

The user is using finasteride, HGH, GHK-CU, BPC-157, KPV, biotin/collagen/keratin vitamins, ketoconazole shampoo, and low-dose naltrexone to address hair loss, avoiding minoxidil due to past shedding experiences. Adenosine is discussed as a potential alternative to minoxidil, though it is noted to be expensive and hard to find.

community 1.5 year on finasteride,microneedling,and minoxidil.Nothing helps its getting even worse.Is it possible that finasteride doesnt work on everybody? 19m

13 upvotes 1 year ago

The user has been using topical finasteride, minoxidil, microneedling, and various supplements for hair loss without success, and is advised to reduce microneedling frequency and consider oral finasteride or dutasteride. It is noted that finasteride may not work for everyone, and some users suggest checking hormone levels and deficiencies.

community 1.5 years on finasteride/rogaine/nizoral

4 upvotes 9 years ago

A 24-year-old experienced initial success with finasteride, Rogaine, and Nizoral for hair loss but noticed a decline after 1.5 years. Despite concerns about side effects, they decided to try dutasteride after consulting with a dermatologist.

community 2019 vs 2022 vs 2026: 1mg oral fin, 0.1% fin + 7% minox topical daily for 2-2.5 years, nizoral 2-3 times weekly, random 0.5-2mm microneedling every 2-3 months

74 upvotes 3 months ago

The user experienced significant hair regrowth using a regimen of 1mg oral finasteride, 0.1% finasteride and 7% minoxidil topical daily, along with nizoral and microneedling. They regained all lost hair and more, achieving a Norwood 1.5 hairline with improved hair and scalp texture.

community a new supplement just released

12 upvotes 8 years ago

A dermatologist recommended a new supplement containing annurca apple, which reportedly doubles hair density and increases keratin after 60 days, to be used with finasteride. Some users are skeptical, considering it potentially ineffective or a marketing ploy, while others are open to trying it if it proves effective and affordable.

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Learn

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learn Overview

learn Keratin

What role does keratin play in strengthening weak or thinning hair? Keratin strengthens hair by forming protective structures that prevent breakage and thinning.
Are keratin treatments good for people with alopecia, or do they only improve the hair’s appearance? Keratin treatments improve hair appearance but do not address alopecia or stimulate growth.
Is keratin in shampoos and conditioners actually absorbed by the hair, or does it just coat the surface? Keratin in shampoos mainly coats the hair rather than being absorbed.
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learn Hydrolyzed Keratin

learn Alpha Keratin

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