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    Glossary Keratin 15

    protein crucial for hair follicle stem cell regulation

    Keratin 15 (K15) is a type of protein found in the hair follicles and skin, playing a crucial role in the structural integrity and function of these tissues. It is particularly important for the maintenance and regeneration of hair, as it is involved in the regulation of stem cells within the hair follicle, which are essential for hair growth and repair.

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    1. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis The Journal of Cell Biology · 2025
    2. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    3. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    4. Expression of the hair stem cell-specific keratin 15 in pilar tumors of the skin. PubMed · 1999 · 54 citations
    5. Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino-Acid Composition and Repeat Structure 2007 · 51 citations
    6. Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro European Journal of Cell Biology · 2010 · 42 citations
    7. Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits Animals · 2019 · 7 citations
    8. Exploring the effects of wetting and free fatty acid deposition on an atomistic hair fiber surface model incorporating Keratin Associated Protein 5-1 2022
    9. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003 · 387 citations
    10. A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse Molecular Carcinogenesis · 2012 · 44 citations
    11. Genomic Organization and Amplification of the Human Keratin 15 and Keratin 19 Genes Biochemical and Biophysical Research Communications · 2000 · 12 citations
    12. Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777] European Journal of Cell Biology · 2012 · 1 citations
    13. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis bioRxiv (Cold Spring Harbor Laboratory) · 2025
    14. An Investigation of Keratin 15 Function by Small Interfering Ribonucleic Acid Technology Durham e-Theses (Durham University) · 2012
    15. Expression of Keratin 15 in Alopecia's Frontal Hair Follicle Zhongguo linchuang yixue · 2007
    16. Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion 2011 · 30 citations
    17. Variation in the ovine keratin-associated protein 15-1 gene affects wool yield The Journal of Agricultural Science · 2018 · 18 citations
    18. Variation in the caprine keratin-associated protein 15-1 (KAP15-1) gene affects cashmere fibre diameter 2019 · 30 citations
    19. Polymorphisms in the Human High Sulfur Hair Keratin-associated Protein 1, KAP1, Gene Family 2002 · 48 citations
    20. Abstract 5022: Keratin15 (Krt15) + are radio resistant and tumor-initiating cells in the mouse small intestine Cancer Research · 2017
    21. A Small Deletion Hotspot in the Type II Keratin Gene<i>mK6irs1/Krt2-6g</i>on Mouse Chromosome 15, a Candidate for Causing the Wavy Hair of the Caracul (<i>Ca</i>) Mutation Genetics · 2003 · 53 citations
    22. Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix Journal of Investigative Dermatology · 2001 · 130 citations
    23. Tunable Keratin Hydrogels for Controlled Erosion and Growth Factor Delivery Biomacromolecules · 2015 · 106 citations
    24. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    25. Keratin K15 as a Biomarker of Epidermal Stem Cells International Journal of Molecular Sciences · 2013 · 85 citations
    26. Alkylation of human hair keratin for tunable hydrogel erosion and drug delivery in tissue engineering applications Acta biomaterialia · 2015 · 75 citations
    27. Deficient Plakophilin-1 Expression Due to a Mutation in PKP1 Causes Ectodermal Dysplasia-Skin Fragility Syndrome in Chesapeake Bay Retriever Dogs PLoS ONE · 2012 · 28 citations
    28. Isolation and Characterization of a Novel Hair Follicle–Specific Gene, Hacl-1 Journal of Investigative Dermatology · 1994 · 25 citations
    29. Characterisation of an Ovine Keratin Associated Protein (KAP) Gene, Which Would Produce a Protein Rich in Glycine and Tyrosine, but Lacking in Cysteine Genes · 2019 · 24 citations
    30. Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression PloS one · 2016 · 14 citations