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Glossary Keratin 14

protein in skin's basal layer providing structural support

Keratin 14 (KRT14) is a type of protein found in the skin, specifically in the basal layer of the epidermis. It plays a crucial role in providing structural support and resilience to skin cells. Mutations in the KRT14 gene can lead to skin disorders such as epidermolysis bullosa simplex, which causes the skin to be fragile and blister easily.

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What role does keratin play in strengthening weak or thinning hair? Keratin strengthens hair by forming protective structures that prevent breakage and thinning.
Are keratin treatments good for people with alopecia, or do they only improve the hair’s appearance? Keratin treatments improve hair appearance but do not address alopecia or stimulate growth.
Is keratin in shampoos and conditioners actually absorbed by the hair, or does it just coat the surface? Keratin in shampoos mainly coats the hair rather than being absorbed.
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Research

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research Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation.

198 citations , November 1989 in “The Journal of Cell Biology”

This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.

research Clinicopathological features and expression of four keratins (K10, K14, K17 and K19) in six cases of eruptive vellus hair cysts

8 citations , April 2014 in “Clinical and Experimental Dermatology”

This study suggests that eruptive vellus hair cysts often have atypical pathological changes and likely originate from the infrainfundibulum and sebaceous duct based on keratin expression analysis.

research Prolactin—a novel neuroendocrine regulator of human keratin expressionin situ

64 citations , January 2010 in “The FASEB Journal”

This study found that prolactin is a key regulator of keratin expression in human hair follicles, enhancing specific keratin types and influencing epithelial stem cell-associated keratins.

research Genetic disorders of keratin: are scarring alopecias a sub-set?

14 citations , July 1994 in “Journal of Dermatological Science”

In this study, transgenic mice expressing a mutant K6 gene developed progressive scarring alopecia and keratosis, suggesting they may model a new keratin disorder.

research KERATINS AND SKIN DISORDERS

28 citations , April 1996 in “Cell biology international”

This review discusses changes in keratin structure or gene expression that result in various skin disorders and reports no new clinical findings.

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community Keratin fibers vs. Gossypium Herbaceum Hair fibers

1 upvotes 2 years ago

The conversation is about comparing keratin hair fibers to Gossypium Herbaceum hair fibers for diffuse hair loss. The user prefers keratin fibers for their durability and is seeking a bulk purchase option.

community Keratin microspheres - breakthrough

14 upvotes 2 years ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community Is keratin fusion bond good alternative to clip on hair patch for diffused thinners

4 upvotes 3 years ago

Keratin fusion bonds are discussed as an alternative to clip-on hair patches for men with diffused thinning. The conversation explores different styling options for hair loss.

community Let's talk keratin products and hair loss

2 upvotes 11 months ago

OP is considering using a keratin gel to improve hair quality and is concerned about its safety and visual impact on a slightly balding crown. Users discuss shampoo frequency, with some suggesting less frequent use for better hair health, but OP prefers regular shampoo and conditioner for silky hair.

community Is Biotin or Keratin shampoo better for hair health/growth

6 upvotes 2 years ago

Biotin and Keratin shampoos are discussed for hair health and growth. Users suggest shampoos alone don't significantly aid hair growth.

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