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Glossary Keratin 14

protein in skin's basal layer providing structural support

Keratin 14 (KRT14) is a type of protein found in the skin, specifically in the basal layer of the epidermis. It plays a crucial role in providing structural support and resilience to skin cells. Mutations in the KRT14 gene can lead to skin disorders such as epidermolysis bullosa simplex, which causes the skin to be fragile and blister easily.

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Research

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research Progenitor cells expressing nestin, a neural crest stem cell marker, differentiate into outer root sheath keratinocytes

12 citations , July 2019 in “Veterinary Dermatology”

The study suggests that nestin-expressing progenitor cells can differentiate into outer root sheath keratinocytes in hair follicles, indicating distinct progenitors for different hair follicle and epidermal components.

DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Keratinocyte Differentiation and Hair Growth

research 1440 DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control keratinocyte differentiation and hair growth

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, the ablation of Tet2/Tet3 genes in mouse skin epithelial cells led to altered hair shape and length, highlighting their role in regulating hair follicle gene expression and chromatin structure.

research Pathological Mechanisms Involved in Epidermolysis Bullosa Simplex: Current Knowledge and Therapeutic Perspectives

9 citations , August 2024 in “International Journal of Molecular Sciences”

This review explores epidermolysis bullosa simplex subtypes caused by mutations in KRT5 or KRT14 and summarizes gene expression patterns and molecular mechanisms, without presenting new experimental results.

Dissecting the Role of the Common Neurotrophin Receptor CD271 in the Skin: Generation and Characterization of a Novel Mouse Model with Keratinocyte-Specific Conditional Deletion

research 186 Dissecting the role of the common neurotrophin receptor CD271 in the skin: generation and characterization of a novel mouse model with keratinocyte-specific conditional deletion

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that conditional deletion of CD271 in mouse epidermis led to significant disorganization and increased thickness, suggesting CD271's crucial role in regulating skin differentiation and structure.

research Lineage Tracing of Hair Follicle Stem Cells in Epidermal Whole Mounts

11 citations , January 2013 in “Methods in molecular biology”

This study describes a method for labeling and tracking hair follicle stem cells in mouse skin using a Cre/lox recombination system with tamoxifen, providing insights into stem cell behavior and contribution to tissue regeneration.

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community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community What else is good. Besides the big 3.

in Chat 35 upvotes 1 year ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Help me choose a daily shampoo (too many options!)

4 upvotes 1 month ago

The user is seeking a gentle, fragrance-free daily shampoo for a sensitive scalp with mild psoriasis, considering options like Cleure, CeraVe, and Vanicream. They are also contemplating using Nizoral once a week despite concerns about its harshness.

community Crown Christmas Miracle: Back From the Dead 💀

2107 upvotes 8 months ago

A 42-year-old man achieved significant hair regrowth in seven months using oral minoxidil, oral dutasteride, topical minoxidil, microneedling, and supplements. He experienced minimal side effects and noted dramatic improvements in hair thickness and health.

community Summary of Procapil video by Haircafe

2 upvotes 1 year ago

Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

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