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This study found that TPA treatment induced expression of keratins K6 and K16 in mouse epidermis, with K6 expressed across all cell layers and K16 only in post-mitotic cells.

A specific gene mutation (Y449H in K10) was found in a patient with severe skin disorder.

This review discusses changes in keratin structure or gene expression that result in various skin disorders and reports no new clinical findings.

In this study, transgenic mice expressing a mutant K6 gene developed progressive scarring alopecia and keratosis, suggesting they may model a new keratin disorder.

Basal cell carcinoma shows keratin patterns similar to undifferentiated hair follicle cells.