learn Alopecia Areata
autoimmune disorder causing patchy hair loss
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7 / 801 results- What makes alopecia areata different from other types of hair loss, and can topical Salicylic acid treatments help regrow the affected areas? Alopecia areata is an autoimmune condition, and salicylic acid does not promote hair regrowth.
- What is tofacitinib, and why is it discussed in relation to autoimmune-related hair loss such as alopecia areata? Tofacitinib is a prescription JAK inhibitor approved for rheumatoid arthritis, psoriatic arthritis and ulcerative colitis — not for alopecia areata. It is discussed for hair loss because a 2014 case report and a 2016 open-label trial reported regrowth in severe alopecia areata, but that use is off-label, the regrowth relapsed after stopping, and the drug carries an FDA boxed warning.
- Heard alopecia areata leaves scar-like spots? Some peptides are helping those areas regrow hair. Alopecia areata patches usually still have living follicles. Peptides are being studied as a possible add-on, but the evidence is small and early. See a dermatologist for treatment.
- Got small bald circles with no warning? Centella creams might calm the area and kickstart new growth. There is no published human trial of Centella asiatica for alopecia areata or any other hair loss; the only hair-related studies are cell-culture work. Community users describe Centella creams as soothing for an irritated scalp, not as regrowth treatments, and a new bald patch needs a doctor's diagnosis first.
- Could cetirizine help control autoimmune triggers in alopecia areata? No published trial has tested cetirizine in alopecia areata; one registered trial has not reported results. Small trials in pattern hair loss report modest benefit, so any use for alopecia areata is off-label and unproven.
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learn Tofacitinib
a JAK inhibitor for alopecia areata and other autoimmune conditions
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learn Baricitinib
JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases
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Research
5 / 1000+ resultsresearch Juvenile versus maturity-onset alopecia areata- a comparative retrospective clinical study
This retrospective study found that juvenile alopecia areata is more severe and has a worse prognosis than maturity-onset alopecia areata.
research 463 Comorbid conditions associated with alopecia areata: A systematic review and update
This study provides an updated systematic review and meta-analysis showing that alopecia areata is associated with significantly higher odds of several autoimmune and metabolic comorbidities compared to healthy controls.
research Coexistence of dermatomyositis and alopecia areata: Insight into pathogenesis
This case report describes a nine-year-old girl with juvenile dermatomyositis and alopecia areata, suggesting a possible etiological link between these coexisting immune-mediated diseases, a previously unreported association.
research Palmoplantar pustulosis–like eruption following tofacitinib therapy for juvenile idiopathic arthritis
This article reviews the use of tofacitinib for rheumatoid and psoriatic arthritis and alopecia areata, noting potential serious side effects, but reports no cases of palmoplantar pustulosis from the therapy.
research Alopecia Areata: Prognostic Factors
This study found that severe forms of alopecia areata may be associated with poor treatment response, particularly in cases with extensive hair loss, juvenile onset, or nail changes.
Community Join
5 / 1000+ resultscommunity A receding hairline is not really problematic as long as you have good density
Maintaining good hair density is more important than preventing a receding hairline, as it can enhance a mature look. Treatments discussed include finasteride, minoxidil, dutasteride, and RU58841.
community A man in his 80s with full head of hair.
Genetics play a major role in hair loss, with some people keeping a full head of hair into old age without using treatments like minoxidil or finasteride. Many express frustration over their own hair loss and the perceived unfairness of genetic differences.
community I don’t think my hair loss is caused by DHT – quitting finasteride after 3 months (1 mg). Need opinions
The user plans to stop finasteride after three months, believing hair loss isn't due to DHT, and will continue with oral minoxidil, microneedling, and ketoconazole shampoo. They suspect stress and poor nutrition are the main causes and seek opinions on DHT blockers' effectiveness.
community Early Signs - Notes for diffuse thinners
Diffuse thinning is often due to androgenetic alopecia, and DHT blockers like finasteride are recommended. Treatments mentioned include minoxidil, finasteride, dutasteride, and RU58841, with emphasis on starting early and using a holistic approach.
community Quote from Pelage (PP-405) Spokesperson...
Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.
Clinics
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Experts
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