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    Glossary JAK1/2 inhibitor

    medication that blocks enzymes involved in immune signaling

    A JAK1/2 inhibitor is a type of medication that blocks the activity of Janus kinase 1 and 2 (JAK1 and JAK2), which are enzymes involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK1/2 inhibitors can help treat conditions like rheumatoid arthritis and certain types of alopecia, where the immune system mistakenly attacks the body's own tissues.

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    Research 10 of 788

    1. 51840 Efficacy of the Oral JAK1/JAK2 Inhibitor Deuruxolitinib in Adult Patients with Moderate to Severe Alopecia Areata: Pooled Results from the Multinational Double-Blind, Placebo-Controlled THRIVE-AA1 and THRIVE-AA2 Phase 3 Trials Journal of the American Academy of Dermatology · 2024 · 2 citations
    2. 41701 Efficacy of the Oral JAK1/JAK2 Inhibitor CTP-543 (Deuruxolitinib) in Adult Patients with Moderate to Severe Alopecia Areata: Results from the Multinational Double-Blind, Placebo-Controlled THRIVE-AA1 Phase 3 Trial Journal of the American Academy of Dermatology · 2023 · 2 citations
    3. Under Development JAK Inhibitors for Dermatologic Diseases Mediterranean Journal of Rheumatology · 2020 · 14 citations
    4. Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature Journal of Dermatological Treatment · 2016 · 40 citations
    5. Which is the ideal JAK inhibitor for alopecia areata – Baricitinib, tofacitinib, ritlecitinib or ifidancitinib - Revisiting the immunomechanisms of the JAK pathway Indian Dermatology Online Journal · 2023
    6. Tofacitinib: The selected selective JAK inhibitor in paediatric dermatology International Journal of Dermatology Venereology and Leprosy Sciences · 2024
    7. A Comprehensive Literature Review of JAK Inhibitors in Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021 · 40 citations
    8. Clinical evidence for JAK inhibition in alopecia areata: A comprehensive review 2026
    9. Small Molecule Inhibitors and Inflammatory Skin Diseases Suez Canal University Medical Journal · 2018
    10. 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells 2023
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