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    Glossary JAK inhibitor

    blocks enzymes involved in immune response and inflammation

    A JAK inhibitor, also known as a Janus kinase inhibitor or JAKi, is a type of medication that blocks the activity of Janus kinase enzymes. These enzymes play a crucial role in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage autoimmune diseases and conditions like alopecia areata, where the immune system mistakenly attacks hair follicles.

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    1. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    2. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015 · 184 citations
    3. Efficacy of JAK 1/2 inhibition in the treatment of diffuse non-scarring alopecia due to systemic lupus erythematosus Annals of the rheumatic diseases · 2020 · 16 citations
    4. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial Journal of the American Academy of Dermatology · 2025 · 2 citations
    5. Effectiveness and safety of oral Janus kinase inhibitors in patients aged ≤12 with alopecia areata: a systematic review and meta-analysis Mendeley Data · 2026
    6. The Effect of JAK Inhibitor on the Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020 · 16 citations
    7. Alopecia universalis with IL-12-RB1 and STAT4 mutations effectively treated with upadacitinib JAAD Case Reports · 2024
    8. Effectiveness of Baricitinib for Nasal, Genital, and Beard Hair Regrowth in Patients with Severe Alopecia Areata: 12-Month Outcomes from a Prospective Observational Study SKIN The Journal of Cutaneous Medicine · 2025
    9. Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe? Frontiers in Immunology · 2024
    10. Ritlecitinib: Efficacy of a Novel Therapy for Severe Alopecia Areata in Patients Aged 12 Years and Older Actas Dermo-Sifiliográficas · 2025
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