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research 1032 Characterization of the human scalp hair follicle microbiome reveals differential spatial distribution, abundance and viability of intrafollicular microbiota and modulation of hair growth and metabolism by staphylococcus epidermidis

April 2023 in “Journal of Investigative Dermatology”

Staphylococcus epidermidis affects hair growth and metabolism, suggesting it could help manage hair growth issues.

research Efficacy of Scalp Cooling in the Prevention of Chemotherapy Induced Alopecia Among Breast Cancer Patients

1 citations , June 2023 in “Sciential - McMaster Undergraduate Science Journal”

This paper reviews scalp cooling as an effective method for preventing chemotherapy-induced alopecia, highlighting recent trials that demonstrate its ability to preserve and regrow hair, thus improving patient well-being.

research Hair Follicle Stem Cell SLC3A2 Regulates Epithelial Regenerative Properties

September 2025 in “Journal of Investigative Dermatology”

This research found that deleting the SLC3A2 gene in hair follicle stem cells disrupts their maintenance and proper differentiation, leading to hair follicle growth defects and altered skin regeneration through a YAP/Taz-dependent pathway.

research The Role of the Vitamin D Receptor in the Epidermal Stem Cell Response to Wounding

August 2024 in “Receptors”

This review highlights the crucial role of vitamin D signaling in epidermal stem cells during skin wound healing, emphasizing its distinct functions from calcium metabolism and its importance in genomic regulation mediated by the vitamin D receptor.

research Activity of type 1 5α-reductase is greater in the follicular infrainfundibulum compared with the epidermis

12 citations , February 1997 in “British Journal of Dermatology”

This study found that 5α–reductase activity is higher in infrainfundibular keratinocytes compared to interfollicular epidermal keratinocytes, suggesting a potential role in acne-related follicular changes.

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community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 1 year ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

121 upvotes 2 years ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community 9 months on Finasteride and still no progress and feeling hopeless

38 upvotes 10 months ago

The user has been using finasteride, minoxidil, microneedling, PRP, and ProCell therapy for hair loss but sees no progress after nine months. They are considering switching to dutasteride and possibly a hair transplant, with suggestions to add oral minoxidil.

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