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research 17α‐estradiol induces aromatase activity in intact human anagen hair follicles ex vivo

94 citations , August 2002 in “Experimental Dermatology”

This study found that 17α‐estradiol increases aromatase activity in female hair follicles, which may explain its beneficial effects in treating androgenetic alopecia.

research K15 & Id3 expression in intact and regenerating adult vibrissae rodent hair follicles

January 2009

This study suggests that keratin 15 and Id3 proteins play distinct roles in epithelial and dermal cell activities during the regeneration stages of rat vibrissae hair follicles.

research Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles

11 citations , January 2018 in “Acta dermato-venereologica”

In this study, researchers identified gremilin-2 as a highly specific gene to the dermal sheath cup, suggesting it plays a key role in maintaining its properties.

research A procedure for the culture of hair follicles as functionally intact organoids

5 citations , October 1988 in “Clinics in Dermatology”

A method was developed to grow hair follicles in a lab for research on hair growth and health.

research 805 Topical thyroid hormones promote hair follicle and epithelial hair follicle stem cell growth in intact human scalp skin ex vivo

July 2024 in “Journal of Investigative Dermatology”

Topical thyroid hormones may boost hair growth.

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community Do hair follicles dies or are dormant ?

in Finasteride/Dutasteride 92 upvotes 1 year ago

Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

community A stress hormone has been found to signal through skin cells to repress the activation of hair-follicle stem cells in mice

30 upvotes 5 years ago

Stress can lead to hair loss by affecting hair-follicle stem cells, and this loss is harder to recover from if one has male pattern baldness (MPB). Treatments like finasteride and minoxidil are used to address hair loss, but stress-related hair loss differs from androgenic alopecia.

community PP405 Effectiveness in Transplant Area?

5 upvotes 8 months ago

Hair transplant recipients are concerned about whether dormant follicles are permanently damaged by incisions, but some believe undamaged follicles could still regrow if a treatment like PP405 is effective. Opinions vary on the impact of transplants on original follicles, with some suggesting treatments like finasteride can help regrow hair.

community The pessimism about the Crisp Cas 9 is excessive

12 upvotes 11 months ago

CRISPR Cas9 could potentially treat baldness by targeting specific genes in hair follicles without affecting other body functions. There is optimism about its future use, despite ethical concerns and the current reliance on treatments like minoxidil and finasteride.

community Can we get a reality check on PP405?

79 upvotes 11 months ago

PP405 is a promising hair loss treatment that may outperform minoxidil and finasteride by reviving dormant follicles and promoting significant regrowth. Results from ongoing trials are awaited, with a potential market release between 2028-2030.

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Clinics

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas