TLDR A method was developed to grow hair follicles in a lab for research on hair growth and health.
The study from 1988 focused on developing a culture system for hair follicles to facilitate research on cellular differentiation, gene expression, and the effects of various factors on hair growth. The researchers aimed to maintain hair follicles as three-dimensional structures using a collagen matrix, which allowed for prolonged analysis. This system was intended to enable the transfection of hair cells with keratin genes and to study the impact of nutritional factors, hormones, drugs, and carcinogens on hair growth and epithelial neoplasms. The success of the culture system was measured by the continued synthesis of hair-specific proteins.
87 citations
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October 1987 in “Journal of Investigative Dermatology” 7 citations
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February 1982 in “Australian Journal of Biological Sciences” Epithelial cells from young rat hair follicles grow and form aggregates in culture, but don't produce hair keratin proteins.
88 citations
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January 1981 in “British Journal of Dermatology” A new method helps grow human hair cells using a cow eye lens.
14 citations
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March 1995 in “Journal of cell science” SV40 T antigen in hair follicles causes abnormal hair and health issues in mice.
159 citations
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July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Immune cells are essential for early hair and skin development and healing.
488 citations
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July 2021 in “Cell” Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.
67 citations
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December 2008 in “Developmental Biology” Msx2 and Foxn1 are both crucial for hair growth and health.
