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    Glossary Inner Root Sheath

    layer of cells supporting and shaping the growing hair shaft

    The Inner Root Sheath (IRS) is a layer of cells that surrounds and supports the growing hair shaft within the hair follicle. It plays a crucial role in shaping the hair and guiding it as it emerges from the scalp. The IRS is composed of three distinct layers: Henle's layer, Huxley's layer, and the cuticle of the inner root sheath, each contributing to the structural integrity and function of the hair follicle.

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    1. K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1 Journal of Investigative Dermatology · 2003 · 130 citations
    2. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle Journal of Investigative Dermatology · 2006 · 93 citations
    3. A Novel Epithelial Keratin, hK6irs1, is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells (Flügelzellen) of the Human Hair Follicle Journal of Investigative Dermatology · 2002 · 86 citations
    4. Fine structure and immunocytochemistry of monotreme hairs, with emphasis on the inner root sheath and trichohyalin‐based cornification during hair evolution Journal of morphology · 2004 · 15 citations
    5. Fine structure of marsupial hairs, with emphasis on trichohyalin and the structure of the inner root sheath Journal of morphology · 2004 · 8 citations
    6. A Novel Type II Cytokeratin, mK6irs, is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath Journal of Investigative Dermatology · 2001 · 45 citations
    7. Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle. PubMed · 1990 · 44 citations
    8. Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans British Journal of Dermatology · 2001 · 38 citations
    9. Abnormal inner root sheath of the hair follicle in the loose anagen hair syndrome: An ultrastructural study Journal of the American Academy of Dermatology · 2010 · 31 citations
    10. Investigation of the hair follicle inner root sheath in scarring and non‐scarring alopecia Journal of Cutaneous Pathology · 2007 · 28 citations
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    1. Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp Reddit · 19 May 2023
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