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research Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis

14 citations , May 2013 in “American Journal of Physiology-endocrinology and Metabolism”

This study found that mice lacking myelin protein zero-like 3 (Mpzl3) had reduced body weight and adiposity despite increased food intake, which was linked to higher energy expenditure and improved glycemic control.

research 548 Deletion of Myelin Protein Zero-like 3 increases sebaceous gland size and sebocyte proliferation but reduces skin adipose depots: Can MPZL3 inhibition promote excessive loss of lipids via sebum hypersecretion?

November 2022 in “Journal of Investigative Dermatology”

This study found that MPZL3 knockout mice showed reduced dermal white adipose tissue and increased sebocyte proliferation, suggesting a regulatory role for MPZL3 in lipid metabolism balance between adipocytes and sebocytes.

research Association of Early Clinical Response to Laser Rejuvenation of Photoaged Skin with Increased Lipid Metabolism and Restoration of Skin Barrier Function

11 citations , August 2022 in “Journal of Investigative Dermatology”

research Long-term dutasteride therapy in men with benign prostatic hyperplasia alters glucose and lipid profiles and increases severity of erectile dysfunction

20 citations , June 2017 in “Hormone Molecular Biology and Clinical Investigation”

This study found that long-term dutasteride therapy in men with benign prostatic hyperplasia worsened erectile dysfunction, reduced testosterone levels, and increased blood glucose and lipid profile, indicating negative metabolic impacts.

research Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T

506 citations , March 2005 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that testosterone therapy improved physical performance and strength in older men with low testosterone over 36 months, whether administered alone or with finasteride.

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community Anyone experienced weight gain on dutasteride?

5 upvotes 4 years ago

Dutasteride can lead to increased cholesterol and liver fat. The user is reconsidering its use due to high cholesterol and lipid levels despite a healthy lifestyle.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

484 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Lipisomal Solution (Dutasteride / Tretinoin & Minoxidil & Tretinoin) Horror Story Warning

in Update 12 upvotes 1 year ago

Using liposomal solutions with dutasteride, minoxidil, and tretinoin worsened hair loss due to buildup and scalp issues. Consulting a professional and returning to simpler treatments like finasteride and minoxidil improved the situation.

community Creatine, my hair loss, and my DHT levels. An anecdote with lab values.

165 upvotes 1 year ago

Increased hair loss after starting a 10g daily creatine regimen, possibly linked to elevated DHT levels despite dutasteride use. Stopping creatine reduced shedding, but the exact cause is uncertain, with discussions on exercise and lifestyle impacts.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

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Learn

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learn Exosomes

Cell-derived vesicles sold by some clinics for hair loss. Experimental, not FDA-approved, with little human evidence.

learn Ketoconazole

Antifungal shampoo; small studies suggest a possible modest benefit in pattern hair loss, but it is not approved for that use. Oral ketoconazole tablets are a different product with a boxed liver warning.

learn Hair Transplant

Does a hair transplant increase hair density? A hair transplant can improve density, but results vary by individual factors.

learn vitamin b2

Can a deficiency in Vitamin B2 cause scalp irritation or increased hair shedding? Severe vitamin B2 deficiency can cause seborrheic-dermatitis-like skin changes, according to the NIH and WHO. It is rare in well-nourished people, and reviews do not identify it as a common cause of hair shedding.

learn zinc PCA

Can a zinc deficiency directly cause hair thinning or increased shedding? Studies link low serum zinc to diffuse shedding and alopecia areata, and severe deficiency states cause hair loss that reverses when zinc is replaced. The evidence is mostly observational, the one supplementation study was small and uncontrolled, and zinc is not a treatment for pattern hair loss.

learn Vascular Endothelial Growth Factor

Are there risks or side effects associated with treatments that increase Vascular Endothelial Growth Factor (VEGF)? Increasing VEGF can lead to risks like abnormal vessel growth and inflammation.

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