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This review discusses the complexities and challenges in treating polycystic ovarian syndrome and concludes that while lifestyle and insulin-sensitizing treatments show promise, randomized controlled trials are lacking.

This study found that genetic polymorphisms of OCT1 influence the effectiveness of metformin treatment in improving insulin sensitivity among PCOS patients, suggesting a role for personalized treatment strategies.

This study found that in women with PCOS, suppressive therapy using spironolactone plus oral contraceptives improved hirsutism more effectively than either treatment alone, with initial scores predicting success.

This study found that in women with polycystic ovary syndrome, a pulse-based diet was more effective than the TLC diet at improving insulin sensitivity and cardiometabolic risk factors, although both diets improved PCOS-specific health outcomes.

This review found that intermittent fasting might benefit skin health by enhancing skin regeneration, delaying aging, and improving inflammatory skin conditions; however, most evidence is based on preclinical data, indicating a need for more human trials to confirm these findings.