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Single Cell Transcriptome Profiling of Human Interfollicular Epidermis Reveals Robust Heterogeneity and Divergent Differentiation Lineages

research Single Cell Transcriptome Profiling of Human Interfollicular Epidermis Reveals Robust Heterogeneity and Divergent Differentiation Lineages

April 2018 in “Journal of Investigative Dermatology”

The human skin's outer layer has more variety in cell types and development paths than previously thought.

research Cytokeratin Expression in Trichoblastic Fibroma, Trichoepithelioma, and Basal Cell Carcinoma

87 citations , January 1999 in “British Journal of Dermatology”

Trichoblastic fibroma and basal cell carcinoma are similar but different from trichoepithelioma.

Fibromodulin Deficiency Alters Temporospatial Expression Patterns of Transforming Growth Factor-β Ligands and Receptors During Adult Mouse Skin Wound Healing

research Fibromodulin Deficiency Alters Temporospatial Expression Patterns of Transforming Growth Factor-β Ligands and Receptors During Adult Mouse Skin Wound Healing

32 citations , March 2014 in “PLOS ONE”

Mice lacking fibromodulin have disrupted healing patterns, leading to abnormal skin repair and scarring.

research Differences in Expression of Specific Biomarkers Distinguish Human Beard from Scalp Dermal Papilla Cells

41 citations , June 2006 in “Journal of Investigative Dermatology”

Beard and scalp hair cells have different gene expressions, which may affect beard growth characteristics.

research Transforming Growth Factor-Alpha Immunoreactivity During Induced Hair Follicle Growth Cycles in Sheep and Ferrets

6 citations , April 1996 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

TGF-alpha is present in sheep and ferret skin and may affect hair growth without directly stimulating cell proliferation.

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community My Theory Of Androgenic Alopecia

in Research/Science 17 upvotes 6 days ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.